Concept explainers
(a)
Interpretation:
The amino acid associated with the hydrophobic side chain needs to be identified.
Concept introduction:
Amino acids are organic compounds with both amino and
Here, R group is different for different amino acids.
(b)
Interpretation:
The amino acid associated with basic side chain needs to be identified.
Concept introduction:
Amino acids are organic compounds with both amino and carboxylic acid groups. The general formula of the amino acid is shown as follows:
Here, R group is different for different amino acids.
(c)
Interpretation:
Theamino acid associated with three ionizable group needs to be identified.
Concept introduction:
Amino acids are organic compounds with both amino and carboxylic acid groups. The general formula of the amino acid is shown as follows:
Here, R group is different for different amino acids.
(d)
Interpretation:
Theamino acid having pKa of about 10 in proteins needs to be identified.
Concept introduction:
Amino acids are the building blocks of proteins and protein plays a vital role in almost all biological processes. A huge proportion of our cells, tissue and muscles are made up of amino acids, means they carry out several significant bodily functions, like, providing cells their structure.
(e)
Interpretation:
The amino acid which is modified form of phenylalanine needs to be determined.
Concept introduction:
Amino acids are organic compounds with both amino and carboxylic acid groups. The general formula of the amino acid is shown as follows:
Here, R group is different for different amino acids.
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Biochemistry
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- A protein gives, under conditions of buffer composition, pH, and temperaturethat are close to physiological conditions, a molecular weight by size exclusion measurements of 140,000 g/mol. When the same protein is studiedby SDS gel electrophoresis in the absence or presence of the reducing agent β-mercaptoethanol (BME), the patterns seen, respectively, in lanes A and B are observed. Lane C contains standards of molecular weight indicated. From these data, describe the native protein, in terms of the kinds of subunits present, the stoichiometry of subunits, and the kinds of bonding(covalent, noncovalent) existing between subunits.arrow_forwardSuppose you have a solution of a protein, which contains a specific Tyr residue that has an actual (measured) pKa of 8.8. The protein binds a ligand by several noncovalent interactions, one of which is a hydrogen bond in which the Tyr phenolic hydroxyl group must serve as a hydrogen bond donor. Calculate the percentage of the protein molecules in which that tyrosyl residue's phenolic hydroxyl group could serve as a hydrogen bond donor at pH 8.5arrow_forwardProtein A is made up of a single polypeptide chain; The molecular mass of A is 20,000 Da; the A molecule has 2 tryptophan residues, 5 tyrosine residues, and no disulfide bonds. Calculate what absorbance (at 280 nm) a solution of protein A will have at a concentration of 1.0 mg / mL, in a 1 cm cell. Write the calculations you have done.arrow_forward
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