Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 21, Problem 19P
Interpretation Introduction

Interpretation:

Reason for the glycogen depletion after strenuous exercise in a mice strain lacking phosphorylase kinase should be explained.

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Explain the Phosphorylation of glycogen phosphorylase by phosphorylase kinase mechanism. What is happening in each step? what are activating nucleophiles and stabilizing intermediates?
How does the activation of AMPactivated protein kinase (AMPK) during aerobic exercise foster the switch to fatty acid oxidation for distance running?
After the training of marathon, lactic acid is accumulated in the athlete's thigh muscle. Compare the physiological functions and Vmax of glycogen phosphorylase in actively working skeletal muscle and that in liver After vigorous exercise, the athlete faints due to low blood glucose level. A liver biopsy test shows excess amount of glycogen is present in the liver. Suggest with explanation, which type of enzyme is defective in this case.
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