Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 21, Problem 41P
Interpretation Introduction

Interpretation:

Another mutation in glucose metabolism that causes symptoms similar to those of von Gierke disease should be suggested.

Concept introduction:

A patient with von Gierke disease has a huge abdomen due to the enlargement of liver. The major symptom is hypoglycemia. The blood glucose levels do not rise even epinephrine and glucagon are given to the patient. Infants with the disease may have convulsions due to low blood glucose levels.

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Suggest an explanation for the fact that the amount of glycogen in type I glycogen-storage disease (von Gierke disease) is increased.
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