Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 21, Problem 41P
Interpretation Introduction
Interpretation:
Another mutation in glucose
Concept introduction:
A patient with von Gierke disease has a huge abdomen due to the enlargement of liver. The major symptom is hypoglycemia. The blood glucose levels do not rise even epinephrine and glucagon are given to the patient. Infants with the disease may have convulsions due to low blood glucose levels.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Pls help ASAP, thank you!
"Which features of glucose metabolism & regulation in the liver are correctly or incorrectly depicted in the figure?"
(all answer choices for the drop down menus are: "correct" or "incorrect")
Modified true or false. Replace the underlined word if false.
Glucagon inhibits beta-oxidation, but stimulates fatty acid biosynthesis.
Suggest an explanation for the fact that the amount of glycogen in type I glycogen-storage disease (von Gierke disease) is increased.
Chapter 21 Solutions
Biochemistry
Ch. 21 - Prob. 1PCh. 21 - Prob. 2PCh. 21 - Prob. 3PCh. 21 - Prob. 4PCh. 21 - Prob. 5PCh. 21 - Prob. 6PCh. 21 - Prob. 7PCh. 21 - Prob. 8PCh. 21 - Prob. 9PCh. 21 - Prob. 10P
Ch. 21 - Prob. 11PCh. 21 - Prob. 12PCh. 21 - Prob. 13PCh. 21 - Prob. 14PCh. 21 - Prob. 15PCh. 21 - Prob. 16PCh. 21 - Prob. 17PCh. 21 - Prob. 18PCh. 21 - Prob. 19PCh. 21 - Prob. 20PCh. 21 - Prob. 21PCh. 21 - Prob. 22PCh. 21 - Prob. 23PCh. 21 - Prob. 24PCh. 21 - Prob. 25PCh. 21 - Prob. 26PCh. 21 - Prob. 27PCh. 21 - Prob. 28PCh. 21 - Prob. 29PCh. 21 - Prob. 30PCh. 21 - Prob. 31PCh. 21 - Prob. 32PCh. 21 - Prob. 33PCh. 21 - Prob. 34PCh. 21 - Prob. 35PCh. 21 - Prob. 36PCh. 21 - Prob. 37PCh. 21 - Prob. 38PCh. 21 - Prob. 39PCh. 21 - Prob. 40PCh. 21 - Prob. 41PCh. 21 - Prob. 42PCh. 21 - Prob. 43PCh. 21 - Prob. 44PCh. 21 - Prob. 45PCh. 21 - Prob. 46P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- "Enzymes dysfunction in liver disorders"- Briefly explain this statement in 500 words, explain at your own wordsarrow_forwardType VI glycogen storage disease (Hers disease) is a rare metabolic disorder caused by lack of phosphorylase kinase in the liver. In your own words describe how each of the following metabolic parameters/observations will be affected/unaffected in a person with Type VI GSD (a) Blood glucose levels, after fasting (e.g. before breakfast). (b) Blood glucose levels, immediately following a meal. (c) Storage of glycogen in the liver and muscles. (d) ATP concentration in the musclesarrow_forwardDescribe the biochemical alterations that result in type 2 diabetes.arrow_forward
- a- During intense exercise the transformation glucose to lactate causes very less ATP production compared to aerobic glycolysis. Explain, does anaerobic glycolysis lead to waste of energy in muscle? b-Glycogen phosphorylase enzyme catalyzes the removal of glucose from glycogen. Describe, glycogen metabolism regulation through glycogen phosphorylase.arrow_forwardHi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.arrow_forwardMULTIPLE CHOICE In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)arrow_forward
- c) Cooperation between glycolysis and gluconeogenesis is important to ensure the glucose-subjected energy demands of specific cells are met. Explain this statement.arrow_forwardMutations in glucokinase which lower the kcat for the enzyme or elevate the Km for glucose result in mild to moderate elevation of blood glucose. Explain how these mutations cause diabetes-like symptoms in patients.arrow_forwardQuestion:- Explain why it makes sense for the PDH complex in liver to be active when dephosphorylated.arrow_forward
- 20. Under a normal metabolic rate which of the following compounds is the most energy rich? Glucose-6-phospate. GTP. NADH. ATP. FADH2.arrow_forwardCompare and contrast glycogen synthesis/degradation in muscles as compared with the liver.arrow_forwardHow GTN works? What are the combination drug therapy are used in managing the hyperlipidemia? Please briefly explain at your own words.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning