Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 21, Problem 34P
Interpretation Introduction

Interpretation:

The way insulin stimulates glycogen synthesis should be explained.

Concept introduction:

When blood-glucose levels are high insulin stimulates glycogen synthesis by inactivating glycogen synthase kinase.

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Ingesting large amounts of glucose before a marathon might seem to be a good way of increasing the fuel stores. However, experienced runners do not ingest glucose before a race. What is the biochemical reason for their avoidance of this potential fuel? (Hint: Consider the effect of glucose ingestion on the level of insulin.)
Explain what biochemical pathway/metabolic processes are affected in insulin resistance? How does this affect glycogen breakdown and gluconeogenesis.
29. Synthesis signal. How does insulin stimulate glycogen synthesis?
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