Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 23, Problem 1EQ
Is each of the following a method used in linkage, cytogenetic, or physical mapping?
A. Fluorescence in situ hybridization (FISH)
B. Conducting two-factor crosses to compute map distances
C. Chromosome walking
D. Examination of polytene chromosomes in Drosophila
E. Use of RFLPs in crosses
F. Using BACs and cosmids to construct a contig
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Given the experimental set up below, and knowing the genes for stalked eyes (st) and black bodies (b) are on the same chromosome and recessive to wild type (un-stalked eyes and light body).
F2= a=489, b=56, c=497, d=49
A) How many recombinant animals are in the F2 generation?
B) ( How far apart, (as both a % recombination and in map units) are the stalk eyed and black bodied genes on this chromosome?
The genetic map was based on crosses in Drosophila involving the three sex-linked genes a, b and c. “a” gives red eyes, “b” gives normal wings and “c” gives black body. The recombination frequencies between these genes are as follows; a and b is 23.8, b and c is 2.6 and a and c is 28.1, respectively. Could you draw a basic genetic map based on distance between these genes using dots to show distance(s)? Could you make one fundamental comment using these distances based on genetic linkage?
Consider the genetic map below. (a) In a total of 1000 observed progeny, how many would be expected to be parental, non-recombinant? (b) If the total number of observed double-crossover recombinant progeny is 0, what is the interference? Show step by step
A-------10cm-----B—2.5cm----C
Chapter 23 Solutions
Genetics: Analysis and Principles
Ch. 23.1 - Prob. 1COMQCh. 23.2 - Prob. 1COMQCh. 23.3 - A molecular marker is a _____ found at a specific...Ch. 23.3 - 2. Which of the following is an example of a...Ch. 23.3 - To map the distance between molecular markers via...Ch. 23.4 - 1. What is a contig?
a. A fragment of DNA that...Ch. 23.4 - A vector that can carry a large fragment of...Ch. 23.4 - 3. Chromosomal walking is a method of _____ in...Ch. 23.5 - Prob. 1COMQCh. 23.5 - Prob. 2COMQ
Ch. 23.5 - 3. A prokaryotic genome is about 4 million bp in...Ch. 23.6 - Metagenomics is aimed at a. determining the...Ch. 23 - 1. A person with a rare genetic disease has a...Ch. 23 - For each of the following, decide if it could be...Ch. 23 - Which of the following statements about molecular...Ch. 23 - 1. Is each of the following a method used in...Ch. 23 - Prob. 2EQCh. 23 - Prob. 3EQCh. 23 - The cells from a persons malignant tumor were...Ch. 23 - 5. Figure 23.2 describes the technique of FISH....Ch. 23 - Explain how DNA probes with different fluorescence...Ch. 23 - 7. A researcher is interested in a gene found on...Ch. 23 - Prob. 8EQCh. 23 - Prob. 9EQCh. 23 - Prob. 10EQCh. 23 - Prob. 11EQCh. 23 - Prob. 12EQCh. 23 - In the Human Genome Project, researchers have...Ch. 23 - 14. Take a look at question 3 in More Genetic...Ch. 23 - 15. Place the following stages of a physical...Ch. 23 - 16. What is an STS? How are STSs generated...Ch. 23 - 17. Four cosmid clones, which we will call cosmids...Ch. 23 - A human gene, which we will call geneX, is located...Ch. 23 - 19. Describe how you would clone a gene by...Ch. 23 - 20. A bacterium has a genome size of 4.4 Mb. If a...Ch. 23 - 21. Discuss the advantages of next-generation...Ch. 23 - Prob. 22EQCh. 23 - Prob. 23EQCh. 23 - What is a molecular marker? Give two examples....Ch. 23 - Which goals of the Human Genome Project do you...
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- How would one explain a testcross involving F1 dihybrid flies in which more parental-type offspring than recombinant-type offspring are produced? Group of answer choices A. The testcross was improperly performed B. The two genes are linked C. Both of the characters are controlled by more than one gene D. The two genes are linked but on different chromosomes E. Recombination did not occur in the cell during meiosisarrow_forwardAlleles of genes A and B were analyzed in Neurospora according to the cross shown below. Ordered tetrads are summarized in each horizontal row with the number of tetrads in each category listed alongside. A) Analyze the data to determine the recombination frequency (RF) between A and B, along with any additional information that is available from this data. B) Draw a map of the chromosome or chromosomes with appropriate map distances. C) Use the Perkins formula to reanalyze any relationship between A and B.arrow_forwardYou design Drosophila crosses to provide recombinationdata for gene a, which is located on the chromosome shownin Figure 15.12. Gene a has recombination frequencies of14% with the vestigial wing locus and 26% with the browneye locus. Approximately where is a located along thechromosome?arrow_forward
- 2. You are making a genetic map and use a cross to measure the distance between genes H and J as 40cMand the distance between J and M as 20cM. When you measure the distance between genes H and M, you get 50 cM. Do the following (A-C). (A) Draw and label a map of genes H, J, and M. (B) What is the genetic distance between genes H and M? How do you know? (Answer in 1 sentence) (C) Complete the table (right). For each pair of genes, write “yes” or “no” to indicate whether the pair of genes are“linked genes” and/orpart of the same“linkage group”.arrow_forwardmapping three linked genes, the heterozygous AaBbCc was crossed to aabbcc individual the following phenotypes were obtained: ABC 4 abc 2 ABc 150 abC 141 aBc 18 AbC 20 Abc 30 aBC 35 A) What are the alleles found on each parental chromosome(genotypes of the parents)? B) How many double recombinants(cross over) were there? c) what is the linear arrangement of loci on the chromosome?arrow_forwardThe wild-type (normal) fruit fly, Drosophila melanogaster, has straight wings and long bristles. Mutant strains have been isolated with either curled wings or short bristles. The genes representing these two mutant traits are located on separate chromosomes. Carefully examine the data from the five crosses below. (a) For each mutation, determine whether it is dominant or recessive. In each case, identify which crosses support your answer; and (b) define gene symbols and determine the genotypes of the parents for each cross.arrow_forward
- . a. A mouse cross A/a ⋅ B/b × a/a ⋅ b/b is made, and inthe progeny there are25% A/a ⋅ B/b, 25% a/a ⋅ b/b,25% A/a ⋅ b/b, 25% a/a ⋅ B/bExplain these proportions with the aid of simplifiedmeiosis diagrams.b. A mouse cross C/c ⋅ D/d × c/c ⋅ d/d is made, and inthe progeny there are45% C/c ⋅ d/d, 45% c/c ⋅ D/d,5% c/c ⋅ d/d, 5% C/c ⋅ D/dExplain these proportions with the aid of simplifiedmeiosis diagrams.arrow_forwardThe wild-type (normal) fruit fly, Drosophila melanogaster, has straight wings and long bristles. Mutant strains have been isolated that have either curled wings or short bristles. The genes representing these two mutant traits are located on separate chromosomes. Carefully examine the data from the following five crosses shown below (running across both columns). (a) Identify each mutation as either dominant or recessive. In each case, indicate which crosses support your answer. (b) Assign gene symbols and, for each cross, determine the genotypes of the parents.arrow_forwardWhich of the following statements about linkage disequilibrium is false? a.) A new mutation first exists in a state of perfect, chromosome-wide linkage disequilibrium b.) Linkage disequilibrium is a statistical state detected when two loci segregate independently c.) Linkage disequilibrium is a transient state that can disappear with genetic recombination d.) Physical linkage is required for two loci to be in a state of linkage disequilibrium.arrow_forward
- Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL. A. What would be the physical phenotype of these flies? B. If PC was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PC products? C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker? D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?arrow_forwardGenes a and b are 20 cM apart. An a+ b+/a+ b+ individual was mated with an a b/a b individual.(a) Diagram the cross and show the gametes produced by each parent and the genotype of the F1.(b) What gametes can the F1 produce, and in what proportions?(c) If the F1 was crossed to a b/a b individuals, what off-spring would be expected, and in what proportions?(d) Is this an example of the coupling or repulsion link-age phase?(e) If the F1 were intercrossed, what offspring would be expected, and in what proportions?arrow_forwardIn a series of two-point map crosses involving five genes locatedon chromosome II in Drosophila, the following recombinant (single-crossover) frequencies were observed:pr–adp 29pr–vg 13pr–c 21pr–b 6adp–b 35adp–c 8adp–vg 16vg–b 19vg–c 8c–b 27 If the adp gene is present near the end of chromosome II(locus 83), construct a map of these genes.arrow_forward
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