(a)
Interpretation:
The chiral carbon(s) in naproxen needs to be determined.
Concept introduction:
For the carbon atom to be chiral, it must be connected to four different atoms or group of atoms.
The point about which compound is non-superimposable on it mirror image is known as chiral centre.
(b)
Interpretation:
Whether naproxen is aromatic or not should be discussed.
Concept introduction:
The compound or molecule is aromatic when:
- It is planar.
- It is cyclic.
- Resonance must be present all over the ring.
- According to Huckel rule, the compound is known as aromatic if it has (4n+2)( electrons.
(c)
Interpretation:
The resonance structure of naproxen is to be drawn.
Concept introduction:
Resonance shows the delocalization of ( electrons in compounds. It is a method which describes the bonding in molecules with the help of various contributing structures known as resonance structures.
(d)
Interpretation:
The sites which can exhibit hydrogen bonding with receptor site is to be circled,
Concept introduction:
Hydrogen bonding is defined as the electrostatic force of attraction between very electronegative atoms (O, F, and N) and hydrogen atoms. It is of two types:
- Inter-molecular hydrogen bonding,
- Intra-molecular hydrogen bonding.
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CHEMISTRY-TEXT
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