Interpretation: The reason corresponding to the fact that organolithium reagents are not used to generate enolates is to be stated.
Concept Introduction: The substitution reaction involves the replacement of one functional group by other functional group. In nucleophilic substitution an electron rich species attack the species that is deficient in electrons. The electrophile and the leaving group together form a substrate. The nucleophile attacks over the substrate and there occurs the removal of leaving group from the substrate.
The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as
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Organic Chemistry
- Which solvent would make the bromination through electrophilic aromatic substitution faster? Pentane Toluene Propanoic acid Petroleum etherarrow_forwardHow does the negative inductive effect (−I) of chlorine in the ortho position of the phenol, reduce the negative charge, located on the oxygen of the phenolate anion? Is this why the Oxygen in the phenolate ion will act as a worse nucleophile if the Chlorine is in the ortho position vs the para position?arrow_forwardDraw a detailed mechanism for the Grignard reaction performed in this experiment, starting from phenylmagnesium bromide and benzophenone and ending with triphenylcarbinol. You do not need to show the mechanism for the formation of phenylmagnesium bromide.arrow_forward
- What functional group cannot be present on the substrate when treating it with either an alkyllithium or Grignard reagent?arrow_forwardWhat is the result of the deprotonation of a malonic ester? I should get an enolate ion, but what does that enolate ion look like?arrow_forwardFill in the reagents necessary for this transformation.arrow_forward
- Write in the reagent necessary for this transformationarrow_forwardThis experiment is aldol condensation reaction. Complete the tablearrow_forwardIn an E2 reaction, what are the characteristics of a good base? How does a chemist tell a strong versus weak or bulky versus not bulky nucleophile? What is the best type of solvent for this reaction? Please define the terms.arrow_forward
- Predict the starting material to make this aldol product.arrow_forwardWhich statement is true with respect to the directing effects of bromine and methoxy groups in electrophilic aromatic substitution reactions? a.Both Br and OMe are meta directors b.Both Br and OMe are ortho/para directors c. Br is a meta director and OMe are ortho/para directors d.Br is a ortho/para directors and OMe are meta directorarrow_forwardAs we learned organolithium reagents (RLi) are strong bases that readilyreact with acidic protons. Why aren't organolithium reagents used to generate enolates?arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning