Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 23.1, Problem 2R
Summary Introduction
To review:
A simple count of the
Given:
Sequence a: AATGCAGGGTATACG
Sequence b: ATTCAGGGTATACC
Introduction:
An ancestral sequence can undergo multiple changes over the time to give rise to the divergent sequences. These changes include insertions, deletions, and single-base substitutions. The differences or divergence between the two sequences may be analyzed by a simple alignment of the sequences.
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Life: The Science of Biology
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- Match the shorter sequence relative to the longer one. Note: Observe Chargaff's rule of base pairing Longer sequence: T C A C G A T C A G C T C G A A G C A C Shorter sequence: T C G T G Clue: More than one correct answerarrow_forwardSuppose you had a method of cutting DNA at specific sequences of nucleotides. how many nucleotides long (on average) would such a sequence have to be in order to make just one cut in a bacterial genome of 3 × 106 nucleotide pairs?arrow_forwardA student has drawn an enlarged portion of a DNA “ladder” model to show two of the nucleotides in greater detail (in the same orientation as they would occur in the ladder model). Which two nucleotides did the student draw?arrow_forward
- Which pair of sequences demonstrate the strongest case of "excess similarity"? a) Two nucleotide sequences that match at 20% of the sites b) Two amino acid sequences that match at 20% of the sites c) Two sequences of 200 amino acids each that match at 10 sites d) Two sequences of 100 nucleotides each that match at 25 sitesarrow_forwardDiscuss why it is useful to search a database to identify sequencesthat are homologous to a newly determined sequence.arrow_forwardWhich of these is not a tool for comparing DNA sequences?arrow_forward
- With regard to Chargaff’s experiment described in Figure shown,answer the following:A. What is the purpose of paper chromatography?B. Explain why it is necessary to remove the bases in order todetermine the base composition of DNA.C. Would Chargaff’s experiments have been convincing if theyhad been done on DNA from only one species? Discuss.arrow_forwardThe goal of many computer programs is to identify sequence elementswithin a long segment of DNA. What is a sequence element? Givetwo examples. How is the specific sequence of a sequence elementdetermined? In other words, is it determined by the computer programor by genetic studies? Explain.arrow_forwardUsing the straight-chain sugar convention where the vertical lines represent sugars and the diagonals are phosphodiester bonds, choose the correct structure of the DNADNA strand that encoded this short stretch of RNA. pppApCpUpGpGpCpApA−OHarrow_forward
- based on the picture What is the length in basepairs of these sequences? How many base substitutions are there between these sequences? Count ONLY the instances where there is ANY nucleotide difference between any of the sequences (leave out any indels in this count) Are there any indels in this alignment? (yes or no)arrow_forwardTranslate the sequence of bases in the previous question, starting at the second base.arrow_forwardUse a drawing to illustrate the principle of DNA gel electrophoresis. Indicate roughly the comparative electrophoretic mobilities of DNAs with 150, 600, and 1200 bp.arrow_forward
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