Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 24.1, Problem 1TQ
Summary Introduction
To review:
The reciprocation of specific immune response to amino acid stretches of 3D antigen.
Introduction:
The immune system of a host is comprised of various biological structures and processes that help in protection against diseases. It consists of major parts like bone marrow, thymus, lymphatic system, complement system, and spleen. There are two types of immunities that are provided by the immune system.
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Which cleavage pattern (indicated by the red triangles in figure below) yields a fragment that has the same antigen-binding avidity as the intact antibody, but is unable to activate complement after binding to a pathogen?
Which of the two antibodies shown in the figure below are most likely to have the same antigen-binding specificity? Explain your reasoning
In the figure below, which close-up view of these two V domains has the amino acid sequences most important for antigen-binding highlighted correctly in red?
Chapter 24 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 24.1 - Prob. 1TQCh. 24.1 - Prob. 2TQCh. 24.1 - Prob. 3TQCh. 24.2 - Prob. 1TQCh. 24.2 - Prob. 2TQCh. 24.2 - Prob. 3TQCh. 24.2 - Prob. 4TQCh. 24.2 - Prob. 5TQCh. 24.3 - Prob. 1TQCh. 24.3 - Prob. 2TQ
Ch. 24.3 - Prob. 3TQCh. 24.4 - Prob. 1TQCh. 24.4 - Prob. 2TQCh. 24.5 - Prob. 1TQCh. 24.5 - Prob. 2TQCh. 24.6 - Prob. 1TQCh. 24.6 - Prob. 2TQCh. 24 - Prob. 1RQCh. 24 - Prob. 2RQCh. 24 - Prob. 3RQCh. 24 - Prob. 4RQCh. 24 - Prob. 5RQCh. 24 - Prob. 6RQCh. 24 - Prob. 7RQCh. 24 - Prob. 8RQCh. 24 - Prob. 9RQCh. 24 - Prob. 10RQCh. 24 - Prob. 11RQCh. 24 - Prob. 12RQCh. 24 - Prob. 13RQCh. 24 - Prob. 14RQCh. 24 - Prob. 15RQCh. 24 - Prob. 16RQCh. 24 - Prob. 17RQCh. 24 - Prob. 18RQCh. 24 - Prob. 19RQCh. 24 - Prob. 20RQCh. 24 - Prob. 1TQCh. 24 - Prob. 2TQCh. 24 - Prob. 3TQCh. 24 - Prob. 4TQCh. 24 - Prob. 5TQ
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- The Adaptive Immune Response Is a Specific Defense Against Infection Name the class of molecules that includes antibodies, and name the five groups that make up this class.arrow_forwardBased on the constant region of the antibodies there are only five iso-types of the antibodies, while millions of different Variable region domains in the variable part of the antibodies. why?arrow_forwardName the two types of antibody light chains.arrow_forward
- In general, what are consequences of activation of the TH1 arm of the immune response? Activation of the TH2 arm?arrow_forwardWhat are three roles played by the Fc domain of an antibody?arrow_forwardWhat is the difference in the kinetics of antibody formation in response to a dirst and second exposure to the same antigen?arrow_forward
- Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.arrow_forwardWhat is the function of the variable regions in an antibody molecule?arrow_forwardCan Ab. Act as antigens? Explain why.arrow_forward
- What is the chemical basis for the specificity of binding of an immunoglobin antibody to a particular antigen? View keyboard shortcutsarrow_forwardWhat is an immunoglobulin? Describe the structure of an immunoglobulin molecule (light chain and heavy chain).arrow_forwardImmunity can be of many types: natural activeimmunity, natural passive immunity, artificial activeimmunity and artificial passive immunity. Which of theseforms of immunity confer immune memory?arrow_forward
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