Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 25, Problem 16CONQ
Summary Introduction
To review:
The segment in which the expression of the gene Antp would occur.
Introduction:
Genes are the basic and smallest unit of hereditary made up of the DNA (deoxyribonucleic acid), which stores genetic information and passes it on from parent to progeny. The term gene was first coined in 1909 by Wilhelm Johannsen. The expression of gene is a process through which the genetic information stored in a gene is used for the making of gene products, which are generally proteins.
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In the module, you have learned about P-element mediated transgenesis in Drosophila and the concept of using transgenes to rescue mutant phenotypes. In the figure below, you will see a wild type fly with its natural eye colour and three mutants with their eye colours changed to vermillion, white and rosy, respectively. A schematic of P-element mediated transgenesis (as shown in the lectures) is also included in the figure. Please inspect the schematic carefully and choose which of the following statements is true:
I.
Injection of the white experimental transgene into the vermillion mutant embryo will not change the vermillion mutant phenotype
II.
Injection of the white experimental transgene in the rosy mutant embryo will change rosy eye colour to red (wild type)
III.
Injection of the white experimental transgene in the white mutant embryo will not change the white mutant phenotype
IV.
Injection of the white experimental transgene in the rosy mutant…
a)
hours: 0 2 567
DMC1
SPS1
hours: 0 2 5 6 7 9 11
DIT1
SPS100
Oxygen level (% normal)
b)
120
100
FIGURE 4.6. Comparison of Northern blots with DNA microarray
data. a) Results from four individual Northern blots examining four different
genes and measuring mRNA production over time, as indicated. b) Results
from a series of microarrays for the same four genes of interest. Note the color
scale on the bottom of b), where bright green indicates a 20-fold repression
and bright red indicates a 20-fold induction. Black indicates no change in
transcription (i.e., the merged microarray spot would have appeared yellow).
80
60
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0 1 2
gene X
gene Y
gene Z
3
1
hour
1.0
1.0
b)
1.0
hours: 0.5 2 5 7 9 11
DMC1
SPS1
DIT1
SPS100
fold repressed
>20 10x 3x3x10x >20
1:1
fold induced
4 5 6 7 8 9 10 11
Time (hours)
3
hour
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4.5
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5
9
hour
hour
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FIGURE 4.7 Transcriptional response of three genes
to the gradual loss of oxygen. a) Graph of oxygen con-
sumption over time by…
As shown in Figure 13-22, how many different transcription factors govern where the Distal-less (Dll) gene willbe expressed?
Chapter 25 Solutions
Genetics: Analysis and Principles
Ch. 25.1 - Prob. 1COMQCh. 25.1 - Prob. 2COMQCh. 25.1 - Which of the following is the correct order for...Ch. 25.2 - Prob. 1COMQCh. 25.2 - Prob. 2COMQCh. 25.2 - Prob. 3COMQCh. 25.2 - Prob. 4COMQCh. 25.3 - Prob. 1COMQCh. 25.3 - Prob. 2COMQCh. 25.3 - 3. Myogenic bHLH proteins are ___________ that...
Ch. 25.4 - Prob. 1COMQCh. 25.4 - Prob. 2COMQCh. 25.5 - 1. A key event that initially determines female or...Ch. 25.5 - Prob. 2COMQCh. 25 - 1. What four types of cellular processes must...Ch. 25 - Prob. 2CONQCh. 25 - Prob. 3CONQCh. 25 - 4. Which of the following statement(s) is/are true...Ch. 25 - Discuss the morphological differences between the...Ch. 25 - Prob. 6CONQCh. 25 - Explain what a morphogen is, and describe how it...Ch. 25 - 8. What is positional information? Discuss three...Ch. 25 - Prob. 9CONQCh. 25 - Prob. 10CONQCh. 25 - 11. Describe the function of the Bicoid protein....Ch. 25 - With regard to development, what are the roles of...Ch. 25 - Discuss the role of homeotic genes in development....Ch. 25 - Describe the molecular features of the homeobox...Ch. 25 - What would you predict to be the phenotype of...Ch. 25 - Prob. 16CONQCh. 25 - If a mutation in a homeotic gene produced the...Ch. 25 - 18. Explain how loss-of-function mutations in the...Ch. 25 - What is the difference between a maternal-effect...Ch. 25 - Prob. 20CONQCh. 25 - Prob. 21CONQCh. 25 - Prob. 22CONQCh. 25 - 23. Discuss the similarities and differences...Ch. 25 - 24. What is cell differentiation? Discuss the role...Ch. 25 - Prob. 25CONQCh. 25 - What is a totipotent cell? In each of the...Ch. 25 - 27. What is a meristem? Explain the role of...Ch. 25 - Prob. 28CONQCh. 25 - Predict the phenotypic consequences of each of the...Ch. 25 - 30. Explain how alternative splicing affects sex...Ch. 25 - Prob. 1EQCh. 25 - Compare and contrast the experimental advantages...Ch. 25 - 3. What is meant by the term cell fate? What is a...Ch. 25 - 4. Explain why a cell lineage diagram is necessary...Ch. 25 - Explain the rationale behind the use of the bag of...Ch. 25 - Prob. 6EQCh. 25 - Take a look at question 2 in More Genetic TIPS...Ch. 25 - All of the homeotic genes inDrosophilahave been...Ch. 25 - Prob. 9EQCh. 25 - wo techniques commonly used to study the...Ch. 25 - Prob. 11EQCh. 25 - Prob. 12EQCh. 25 - 13. Another way to study the role of proteins...Ch. 25 - 14. Why have geneticists used reverse genetics to...Ch. 25 - Prob. 1QSDCCh. 25 - Prob. 2QSDCCh. 25 - Prob. 3QSDC
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- The transcription factor Pax6 is required continually during the life of a mouse (or a human) for the development of the retina. Homozygous Pax6 knockout mice die soon after birth because Pax6 protein is also required in essential organs, such as the pancreas. a) In order to study the role of Pax6 in eye development a researcher wants to generate a mouse that expresses Pax6 everywhere except in its eyes. Describe how you could construct such a mouse by floxing the gene. Is it possible to achieve the same end with a transgene? (Hint: think about using cDNA and RNAI) b) Suppose you want to create a mouse similar to that in part (a), but one where the eye cells from Pax6 function has been removed and now express a gene that specifies a green fluorescent protein (GFP). Marking the cells in this way will allow the investigators to see the shapes of the Pax6- eye cells more easily than if they did not express GFP. Diagram a Pax6 gene construct that would enable the researcher to do this…arrow_forwardWhat are the functions of transcriptional activator proteins and repressor proteins? Explain how they work at the molecular level.arrow_forwardWhy did the TIP-containing oocytes burst in the hypotonic environment? Would this have happened if the researchers had injected plant cells with TIP mRNA?arrow_forward
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