(a)
Interpretation:
Results in the graph are to be determined.
Concept introduction:
Lesch-Nyhan syndrome is an X-linked inherited disorder. It affects about 380,000 people across the globe. Due to this uric acid gets accumulated in the blood and urine, leading to hyperuricemia and hyperuricosuria. This also leads to gout and kidney problems.
(b)
Interpretation:
The reason for the Lasch-Nyhan syndrome in LND1 person is to be determined.
Concept introduction:
Lesch-Nyhan syndrome is an X-linked inherited disorder. It affects about 380,000 people across the globe. Due to this uric acid gets accumulated in the blood and urine, leading to hyperuricemia and hyperuricosuria. This also leads to gout and kidney problems.
(c)
Interpretation:
Explanation for the graph B is to be determined.
Concept introduction:
Lesch-Nyhan syndrome is an X-linked inherited disorder. It affects about 380,000 people across the globe. Due to this uric acid gets accumulated in the blood and urine, leading to hyperuricemia and hyperuricosuria. This also leads to gout and kidney problems.
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BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
- Using the ActiveModel for aldose reductase, describe the structure of the TIM barrel motif and the structure and location of the active site.arrow_forwardNormal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells defective in thymidylate synthase survive and grow. Explain.arrow_forwardThe reaction mechanism of alpha-amylase going through a Nelson Somagyi Assay. (please draw the structure of the steps)arrow_forward
- The nitrogenase complex can reduce molecules other than N2. Provide the structures for the products for each of the following substrates (real and hypothetical) that contain triple bonds: hydrogen cyanide, dinitrogen, and acetylene.arrow_forwardPlz answer correctly do not copy. Question- Arsinate binds to reduced thio groups such as those found in cystiene residues in proteins, lipoate or glutathione. The resulting inhibition leads to central nervous system pathologies. The binding of arsinate to the dihydrolipoyl groups inhibits which of the following enzyme(s)? succinate dehydrogenase malate dehydrogenase pyruvate dehydrogenase complex branched-chain amino acid dehydrogenase complex isocitrate dehydrogenase alpha-ketoglutarate dehydrogenase complexarrow_forwardLactate dehydrogenase is a tetramer of MW 134000 g/mole composed of subunits which are equal in size. It is found in the cytoplasm of eukaryotic and prokaryotic cells. Describe the secondary, tertiary and quaternary structures of lactate dehydrogenase.arrow_forward
- Decoupling agents such as 2,4-DNP can result in altered metabolic activity. Explain what 2,4-DNP is, describe how it alters metabolic activity, and why this could be dangerous.arrow_forwardWhat will be the products? Which enzyme will catalyzes this reaction?arrow_forwardLysozyme’s use of aspartic acid and glutamic acid, to break the glycosidic bonds of the eubacterial cell wall (composed of peptidoglycan), illustrates the common enzymatic pattern of: hydrolysis (catabolic), using nonpolar amino acids at the active site hydrolysis (catabolic), using polar amino acids at the active site condensation (anabolic), using nonpolar amino acids at the active site condensation (anabolic), using polar amino acids at the active site all of the abovearrow_forward
- In the first step of the aldolase reaction, an active site Lys229 residue, with its side chain amino group in the deprotonated state, acts as a nucleophile and attacks the carbonyl C2 carbon of fructose 1,6-bisphosphate to form a Schiff base (boxed in the scheme). Since the pKa of the Lys side chain amino group in free solution is ~10.5, the pKa of Lys229 side chain must have been perturbed to a (higher lower) value for the enzyme to be active at neutral pH. the answer should include sufficient details, including the definition of pKa.arrow_forwardThe text describes a form of gout that results from HGPRT deficiency. Propose one or two additional enzyme abnormalities that might similarly lead to hyperuricemia.arrow_forwardCells defective in thymidylate synthase are able to undergo cell division if methotrexate and thymidine are both provided; however, cells with fully functional thymidylate synthase cannot divide under these same culture conditions. What is the biochemical basis for this observation?arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning