BIO 1406/07 W/CONNECT/LM NEW >IC<
16th Edition
ISBN: 9781260075762
Author: Raven
Publisher: MCG CUSTOM
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Textbook Question
Chapter 25, Problem 6U
Which of the following statements about Pax6 is false?
a Pax6 has a similar function in mice and flies
b. Pax6 is involved in eyespot formation in ribbon worms.
c Pax6 is required for eye formation in Drosophila.
d. Pax6 is required for eyespot formation in planaria.
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In Xenopus, one of the substrates of mitotic CDKs is the phosphatase Cdc25. When phosphorylated by mitotic CDKs, Cdc25 is activated. What is the substrate of Cdc25? How does this information help to explain the rapid rise in mitotic CDK activity as cells enter mitosis?
2) This diagram shows the signaling pathway involved in transducing
extracellular matrix (ECM) signals to induce S-phase progression. Briefly:
ECM (shown in green) binds to and activate integrins which bind to and
activate Ras which binds to and activate Raf which binds to and activate
MEK, which.... etc (you get the idea) until Erk activates cyclinD which the
form a complex with CDK4/6. For the purpose of this problem, we consider
that the signals provided by the ECM through this pathway are necessary
and sufficient for the cell to enter S phase.
Erk
Integrin
Erk
Ras
Raf
MEK
Cyclin D
Cyclin D
CDK4/6
S phase
A) In your studies of the cell cycle, you isolated a new cell line called
mutRAS2 cells. Unlike normal wild type cells, you find that Ras is always bound to GTP in mutRAS2 cells.
Describe how the cell cycle differs between mutRAS2 cells and normal cells when ECM is not present.
Explain your reasoning:
B) In another mutant cell (named mutCD2), you found that a cyclinD mutation…
Which of the following is NOT true about the specification of the eye field? (Check all that apply)
A
ET induces RX, which in turn induces Otx2 and Pax6.
B During late gastrulation, the forebrain and hindbrain are specified.
Pax6 initiates the expression of a network of transcription factors, some of which mutually activate one another.
D
ET induces RX, which in turn induces Pax6 and blocks Otx2 within the eye field.
ET induces RX, which in turn blocks Otx2 and Pax6.
F During early gastrulation, Noggin promotes the expression of both ET and Otx2.
During late gastrulation, Otx2 blocks the inhibition of ET by Noggin.
H) It starts with neural induction when the neural plate is induced within the ectoderm.
Pax6 is only required for the specification of the retina.
During early gastrulation, Noggin indices Otx2 but blocks ET.
E Feedback
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Chapter 25 Solutions
BIO 1406/07 W/CONNECT/LM NEW >IC<
Ch. 25 - Heterochrony is a. the alteration of the spatial...Ch. 25 - Vast differences in the phenotypes of organisms as...Ch. 25 - Homoplastic structures a can Involve convergence...Ch. 25 - Hox genes are a. found in both plants and animals....Ch. 25 - The Brachyury and Thx5 in vertebrates and the Ap3...Ch. 25 - Which of the following statements about Pax6 is...Ch. 25 - Which of the following statements about TbxS is...Ch. 25 - Prob. 8UCh. 25 - Transcription factors are a. genes. b. sequences...Ch. 25 - Independently derived mutations of the CTC gene in...
Ch. 25 - Prob. 1ACh. 25 - Prob. 2ACh. 25 - The Eda allele that causes reduced armor...Ch. 25 - Prob. 4ACh. 25 - The paired-like homeodomain transcription factor 1...Ch. 25 - From the chapter on evolution of development it...Ch. 25 - Phenotypic diversity among major groups of...Ch. 25 - Critique the argument that eyes have multiple...Ch. 25 - Prob. 5SCh. 25 - Having read all of this chapter return to the clam...
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