Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
12th Edition
ISBN: 9780134811390
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 26, Problem 1CS
In a region of Quebec, Canada, 1 in 22 people are heterozygous for the mutant tyrosinemia allele. Using the frequency of heterozygotes, calculate the frequency of recessive homozygotes in this population. What might explain the difference between the frequency of tyrosinemia in the U.S. population and in this particular Canadian population?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Sickle cell anemia is caused by a recessive allele at a single gene. As we discussed in class, being a homozygote for the sickle cell allele is almost always lethal, but heterozygotes tend to be resistant against malaria although they have a mild form of anemia. Because of this heterozygote advantage, the allele for sickle cell anemia has a frequency of more than 10% in some human populations.
How would present allele frequencies of the sickle cell allele change, if there was no heterozygote advantage or disadvantage (that is, that heterozygotes would be identical to ‘normal’ homozygotes – no malaria resistance, no anemia)? How would the change in sickle cell allele frequencies compare to scenario a (extirpation of malaria)
The amount of enzyme activity in a cell that is homozygous for a mutant allele is 20 units. The amount of enzyme activity in a cell homozygous for the WT allele is 10 units. It is known that 14 units of enzyme activity is required to show the trait. What is the dominance relationship between the WT and mutant allele for the phenotype of amount of enzyme per cell?
A) The WT allele is dominant.
B) The mutant allele is dominant.
C) The WT and mutant alleles are codominant.
D) The WT and mutant alleles show incomplete dominance.
E) It is impossible to determine from the information given.
Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?
Chapter 26 Solutions
Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
Ch. 26 - The ability to taste the compound...Ch. 26 - Determine whether the following two sets of data...Ch. 26 - If the albino phenotype occurs in 1/10,000...Ch. 26 - A prospective groom, who is unaffected, has a...Ch. 26 - In a region of Quebec, Canada, 1 in 22 people are...Ch. 26 - Critics argue that a uniform panel of disorders...Ch. 26 - Others argue that the current testing system...Ch. 26 - HOW DO WE KNOW? Population geneticists study...Ch. 26 - CONCEPT QUESTION Read the Chapter Concepts list on...Ch. 26 - Price et al. [(1999).J. Bacteriol181:2358-2362)...
Ch. 26 - The genetic difference between two Drosophila...Ch. 26 - The use of nucleotide sequence data to measure...Ch. 26 - Prob. 6PDQCh. 26 - What must be assumed in order to validate the...Ch. 26 - In a population where only the total number of...Ch. 26 - If 4 percent of a population in equilibrium...Ch. 26 - Consider a population in which the frequency of...Ch. 26 - If the initial allele frequencies are p = 0.5 and...Ch. 26 - Under what circumstances might a lethal dominant...Ch. 26 - Assume that a recessive autosomal disorder occurs...Ch. 26 - One of the first Mendelian traits identified in...Ch. 26 - Describe how populations with substantial genetic...Ch. 26 - Achondroplasia is a dominant trait that causes a...Ch. 26 - Prob. 17PDQCh. 26 - Prob. 18PDQCh. 26 - A botanist studying water lilies in an isolated...Ch. 26 - A farmer plants transgenic Bt corn that is...Ch. 26 - In an isolated population of 50 desert bighorn...Ch. 26 - To increase genetic diversity in the bighorn sheep...Ch. 26 - What genetic changes take place during speciation?Ch. 26 - Some critics have warned that the use of gene...Ch. 26 - Prob. 25PDQCh. 26 - What are the two groups of reproductive isolating...Ch. 26 - A form of dwarfism known as Ellisvan Creveld...Ch. 26 - The original source of new alleles, upon which...Ch. 26 - A number of comparisons of nucleotide sequences...Ch. 26 - Shown below are two homologous lengths of the...Ch. 26 - Recent reconstructions of evolutionary history are...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A total of 1000 members of a Central American population are typed for the ABO blood group. In the sample, 421 have blood type A, 168 have blood type B, 336 have blood type O, and 75 have blood type AB. Part A Use this information to determine the frequency of ABO blood group alleles in the sample. Recall that when considering genes with three alleles whose frequencies are represented by the variables p, q, and r, the sum of genotype frequencies resulting from trinomial expansion is: (p+q+r)² =p² + 2pq+q2+2pr+r²+2gr = 1arrow_forwardAn autosomal locus has alleles A and a. We are given the frequency of individuals with the autosomal recessive phenotype. Which of the following statements is TRUE? Choose all that are true. Note: HWE = Hardy-Weinberg equilibrium a) If we assume HWE, we can calculate both allele frequencies b) If we assume HWE, we can calculate the genotype frequencies that we weren't given c) We can calculate both allele frequencies even if we don't assume HWE d) We can calculate q = Freq(a) even if we don't assume HWE e) Even if we don't assume HWE, we can calculate the genotype frequencies that we weren't givenarrow_forwardAssume an ideal diploid population of size 2N=32 (Just like the Buri Drosophila drift experiment with 16 individuals, or 32 gene copies, every generation). a) What is the probability that a neutral allele present in exactly 16 copies will CHANGE BY FEWER than 2 copies in the next generation? Be sure you understand that this includes cases where the number of copies remains unchanged, as well as the cases (plural!) where the magnitude of change between generations is one. b) What is the ultimate probability of fixation for this allele by drift? c) In the same population, what is the probability that a neutral allele present in exactly 2 copies will change by fewer than 2 copies (same meaning as above) in the next generation? d) What is the ultimate probability of fixation for this allele by drift?arrow_forward
- The cystic fibrosis allele is recessive. The frequency of cystic fibrosis is 0.000484, or about one in 2000 people. Calculate the allele frequencies. What portion of people are carriers (heterozygotes) for cystic fibrosis?arrow_forward8% of XY individuals are color blind in a population. Assume Hardy-Weinberg conditions. Submit your answer as it is. a) What is the percentage of color-blind XX individuals? b) What is the percentage of XX individuals who are carriers? c) If this population has 1000 individuals with 50% of male and 50% of female, how many carriers are present in this population? Submit your answer as it is. Do not round up.arrow_forwardIn the plant Lotus corniculatus, cyanogenic glycoside protects againstinsect pests and even grazing by cattle. The presence of this glycoside inan individual plant is due to a simple dominant allele. A population of L.corniculatus consists of 77 plants that possess cyanogenic glycoside and56 that lack the compound. What is the frequency of the dominant allele responsible for the presence of cyanogenic glycoside in this population?arrow_forward
- What is the first variable that can be calculated given these data, and what is the final variable we are requesting you to calculate? "In Finland, 256 people out of 10,000 are homozygous for the CCR5 allele mutation resulting in HIV resistance. Assuming the locus is in Hardy-Weinberg equilibrium, what is the expected genotype frequency of heterozygous carriers for the CCR5 mutation?"arrow_forwardThis is a classic data set on wing coloration in the scarlet tiger moth (Panaxia dominula). Coloration in this species had been previously shown to behave as a single-locus, two-allele system with incomplete dominance. Data for 1612 individuals are given below: White-spotted (AA) =1469 Intermediate (Aa) = 138 Little spotting (aa) =5 Calculate the following frequencies: A=, a=, AA=, Aa=, aa=arrow_forwardCystic fibrosis (CF) is a recessive autosomal disorder. In certainpopulations of Northern European descent, the number of peopleborn with this disorder is about 1 in 2500. Assuming Hardy-Weinberg equilibrium for this trait:A. What are the frequencies for the common (non-disease-causing)allele and the mutant (disease-causing) allele.B. What are the genotype frequencies of homozygous unaffected,heterozygous, and homozygous affected individuals?C. Assuming random mating, what is the probability that twophenotypically unaffected heterozygous carriers will chooseeach other as mates?arrow_forward
- Butterflies show 3 phenotypes due to incomplete dominance at the D locus with alleles DY and DB giving green phenotype in heterozygotes and yellow and blue in homozygotes. a) A population of butterflies showed 49% yellow, and 51% blue and green. What percentage of the gametes for the next generation would contain the DB allele? b) In another population only 1% of the butterflies are blue, what is the DY allele frequency? c) If the butterflies were subject to predation by birds that could easily detect blue & yellow individuals what effect would you expect this to have on the genotype and allele frequencies over time? Indicate possible percentages.arrow_forwardConsider a situation where F1 is backcrossed with one of its parental lineage and we obtained A1H1/A2H2 : A2H1/A2H2 : A2H2/A2/H2: A1H2/A2H2 = 295 : 186 : 310 : 209, where A1 and A2 are alleles at a locus and H1 and H2 are alleles at the other locus. What is the recombination (genetic) distance between the two loci in centimorgans? A. 8.9 B. 22.5 C. 18.4 D. 50 E. 39.5arrow_forwardNieman-Pick Syndrome involves a defective enzyme, sphyngomylinase. It is usually fatal before the age of 3. The defective allele frequency is 0.01 in Ashkenazi populations. Let’s call the healthy allele A, and the lethal allele a. a) What is the frequency of allele A? Assuming Hardy-Weinberg equilibrium, how many people do you expect to have the three genotypes in a population of 10,000? b) AA:_______ c) Aa:________ d) aa:_________arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
How to solve genetics probability problems; Author: Shomu's Biology;https://www.youtube.com/watch?v=R0yjfb1ooUs;License: Standard YouTube License, CC-BY
Beyond Mendelian Genetics: Complex Patterns of Inheritance; Author: Professor Dave Explains;https://www.youtube.com/watch?v=-EmvmBuK-B8;License: Standard YouTube License, CC-BY