Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
12th Edition
ISBN: 9780134811390
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 26, Problem 13PDQ
Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.
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Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.
Assume that the frequency of an allele that causes an autosomal recessive disease is 0.03. What is the probability of a person having the disease when his or her parents are unrelated (i.e., mating is random)? What is the probability of having the disease when the parents are first cousins? What about when the parents are second cousins?
The incidence of a rare autosomal recessive genetic disorder, Tay-Sachs, is approximately 1 in
3,500 in a certain population. Assuming that this population is in Hardy-Weinberg equilibrium,
what is the probability that a phenotypically normal female with no family history, and a
phenotypically normal male who had an affected great-aunt, will have a child who is a carrier for
Tay-Sachs?
Chapter 26 Solutions
Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
Ch. 26 - The ability to taste the compound...Ch. 26 - Determine whether the following two sets of data...Ch. 26 - If the albino phenotype occurs in 1/10,000...Ch. 26 - A prospective groom, who is unaffected, has a...Ch. 26 - In a region of Quebec, Canada, 1 in 22 people are...Ch. 26 - Critics argue that a uniform panel of disorders...Ch. 26 - Others argue that the current testing system...Ch. 26 - HOW DO WE KNOW? Population geneticists study...Ch. 26 - CONCEPT QUESTION Read the Chapter Concepts list on...Ch. 26 - Price et al. [(1999).J. Bacteriol181:2358-2362)...
Ch. 26 - The genetic difference between two Drosophila...Ch. 26 - The use of nucleotide sequence data to measure...Ch. 26 - Prob. 6PDQCh. 26 - What must be assumed in order to validate the...Ch. 26 - In a population where only the total number of...Ch. 26 - If 4 percent of a population in equilibrium...Ch. 26 - Consider a population in which the frequency of...Ch. 26 - If the initial allele frequencies are p = 0.5 and...Ch. 26 - Under what circumstances might a lethal dominant...Ch. 26 - Assume that a recessive autosomal disorder occurs...Ch. 26 - One of the first Mendelian traits identified in...Ch. 26 - Describe how populations with substantial genetic...Ch. 26 - Achondroplasia is a dominant trait that causes a...Ch. 26 - Prob. 17PDQCh. 26 - Prob. 18PDQCh. 26 - A botanist studying water lilies in an isolated...Ch. 26 - A farmer plants transgenic Bt corn that is...Ch. 26 - In an isolated population of 50 desert bighorn...Ch. 26 - To increase genetic diversity in the bighorn sheep...Ch. 26 - What genetic changes take place during speciation?Ch. 26 - Some critics have warned that the use of gene...Ch. 26 - Prob. 25PDQCh. 26 - What are the two groups of reproductive isolating...Ch. 26 - A form of dwarfism known as Ellisvan Creveld...Ch. 26 - The original source of new alleles, upon which...Ch. 26 - A number of comparisons of nucleotide sequences...Ch. 26 - Shown below are two homologous lengths of the...Ch. 26 - Recent reconstructions of evolutionary history are...
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- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardThe cystic fibrosis allele is recessive. The frequency of cystic fibrosis is 0.000484, or about one in 2000 people. Calculate the allele frequencies. What portion of people are carriers (heterozygotes) for cystic fibrosis?arrow_forwardIn a population of Hopi indians the autosomal recessive gene for albinism exists at an allele frequency of 0.04. What proportion of these individuals are expected to be heterozygous?arrow_forward
- Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. Individuals with PKU have two recessive alleles and have very low levels of an enzyme that is needed to properly break down proteins. If a woman and her husband are both carriers and have three children, what is the probability of each of the following? Show your math. (Hint: You can represent your probabilities as fractions or decimals, but probabilities are always between 0 and 1) a. All three children are of normal phenotype. b. One or more of the three children have the disease. c.All three children have the disease.arrow_forwardIf the frequency of those homozygous for a specific mutation that causes an autosomal monogenic recessive condition in a given population of 2 million individuals is 1/18900, how many individuals are likely to be carriers of the causative mutation? Please give your answer as a whole number.arrow_forwardIn a hypothetical population of 2500 people, 2275 people have brown eyes and 225 people have blue eyes (the homozygous-recessive phenotype). If there are 4000 children produced by this generation, how many (i.e., what number) of the children would be expected to be heterozygous for eye color?arrow_forward
- Use the following information to answer the next question. Galactosemia is an autosomal recessive disorder. In this disorder, the digestive system is unable to digest the sugar galactose properly. It is a rare disorder that only one in about 30 000-50 000 Caucasian children in North America and Europe are born with. The frequency of the dominant allele in a population of 35 000 children, in which 1 is suffering from galactosemia, isarrow_forwardExcessive secretion of male sex hormones results in premature sexual maturation in males and masculization of the sex characters in females. This disorder is called the adrenogenital syndrome, and in Switzerland there is an autosomal recessive form of the disease that affects about one in 5000 newborns. a. Assuming random mating, what is the allele frequency of the recessive? b. What is the frequency of heterozygous carriers?arrow_forwardIf the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/8500 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol. ANSWER: In a population where the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known mutation is 1/8500 the carrier frequency is a percent.arrow_forward
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