Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
12th Edition
ISBN: 9780134811390
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 26, Problem 28ESP

The original source of new alleles, upon which selection operates, is mutation, a random event that occurs without regard to selectional value in the organism. Although many model organisms have been used to study mutational events in populations, some investigators have developed abiotic molecular models. Soil et al. (2006. Genetics 175: 267-275) examined one such model to study the relationship between both deleterious and advantageous mutations and population size in a ligase molecule composed of RNA (a ribozyme). Soil found that the smaller the population of molecules, the more likely it was that not only deleterious mutations but also advantageous mutations would disappear. Why would population size influence the survival of both types of mutations (deleterious and advantageous) in populations?

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Microbiologists have discovered that alleles associated with antibiotic resistance are present in bacteria that live in soil, even in environments that are comparatively free of antibiotic pollution from human activities. Why are such alleles present (albeit at low levels) in bacterial populations? Conversely, if resistance alleles are beneficial, why are they rare in natural populations of bacteria?
1a) In a very large population, if the forward and reverse mutation rates are exactly the same, how would you expect the frequency of an original, non-mutated allele to change in the population over time? Will the population eventually achieve an equilibrium value of the frequency of the non-mutated allele? b) What if the forward mutation rate is one order of magnitude larger (e. 10X) than the reverse mutation rate? Do you expect the frequency of the original, non-mutated allele to increase, decrease, or stay the same over time?  c) If the population size is considerably smaller, does this change your expectations for changes in the frequency of the original, non-mutated allele over several generations?
The use of nucleotide sequence data to measure genetic variability is complicated by the fact that the genes of higher eukaryotes are complex in organization and contain 5′ and 3′ flanking regions as well as introns. Researchers have compared the nucleotide sequence of two cloned alleles of the g-globin gene from a single individual and found a variation of 1 percent. Those differences include 13 substitutions of one nucleotide for another and 3 short DNA segments that have been inserted in one allele or deleted in the other. None of the changes takes place in the gene’s exons (coding regions). Why do you think this is so, and should it change our concept of genetic variation?

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Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)

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