EBK CONCEPTS OF GENETICS
12th Edition
ISBN: 9780134818979
Author: Killian
Publisher: YUZU
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Chapter 26, Problem 2NST
Determine whether the following two sets of data represent populations that are in Hardy-Weinberg equilibrium.
- (a) CCR5 genocypes: 1/1, 60 percent; 1/Δ32, 35.1 percent; Δ32/Δ32, 4.9 percent
- (b) Sickle-cell hemoglobin: SS, 75.6 percent; Ss, 24.2 percent; ss, 0.2 percent (S = normal hemoglobin allele; s = mutant hemoglobin allele)
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Students have asked these similar questions
The following frequencies were gathered in an African population affected with sickle-cell anemia: SS, 75.5%; Ss, 23.0%; ss, 1.5% (S = normal hemoglobin allele; s = mutant hemoglobin allele). Calculate the genotypic frequencies and determine whether this data represent a population that is in HWE.
A study on blood types in a population found the following genotypic distribution among the people sampled: 1101 were MM, 1496 were MN and 503 were NN.
i) calculate the allelic genotypic frequencies.
ii) using x² test, determine whether or not this population is in Hardy-Weinberg equilibrium. Important information from the x² distribution is given in the picture attached.
Table 1. Use the numbers of individuals with each of the three CCRS genotypes among 1318 Caucasian blood
donors, to fill in the empty boxes (Data Source: Glass et al. 2006)
Numbers observed
Frequency observed (round to 3 decimal
places)
Frequency expected for population in HWE
(round to 3 decimal places)
+/+
Numbers of individuals expected (frequency
expected times 1318, round to nearest
whole number)
1102
Genotypes
+/A32
Use the data above to calculate allele frequencies. Freq of +
Freq of 432
203
432/432
13
(round to 3 decimal places)
row must
sum to -1
values
must sum
to-1
row must
sum to-1
row sums
to 13187
Chapter 26 Solutions
EBK CONCEPTS OF GENETICS
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