Biology: Concepts and Investigations
5th Edition
ISBN: 9781260542202
Author: Marielle Hoefnagels
Publisher: Mcgraw-hill Higher Education (us)
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Chapter 29.7, Problem 2MC
Summary Introduction
To describe:
The data given in figure 29.21 and the conclusions that researchers drew from these data.
Concept introduction:
Mutations are the changes that take place in the genes of any organism. Genes are those portions of chromosomes that code a functional protein. All the proteins, traits, features and factors that are present in an organism are a result of genes present in an organism. Mutations in these genes make them non-functional or cause the genes to make a defective protein that finally and mostly are harmful and deleterious for that organism in which mutation take place.
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Chapter 29 Solutions
Biology: Concepts and Investigations
Ch. 29.1 - How do the skeletal and muscular systems interact?Ch. 29.1 - Prob. 2MCCh. 29.2 - What are the components of the axial and...Ch. 29.2 - Prob. 2MCCh. 29.3 - Prob. 1MCCh. 29.3 - What are the differences between spongy bone and...Ch. 29.3 - Prob. 3MCCh. 29.3 - Prob. 4MCCh. 29.3 - Prob. 5MCCh. 29.4 - Prob. 1MC
Ch. 29.4 - Prob. 2MCCh. 29.4 - How do ATP, motor neurons, and calcium ions...Ch. 29.5 - Prob. 1MCCh. 29.5 - Prob. 2MCCh. 29.6 - Prob. 1MCCh. 29.6 - Prob. 2MCCh. 29.6 - Prob. 3MCCh. 29.7 - Prob. 1MCCh. 29.7 - Prob. 2MCCh. 29 - Prob. 1MCQCh. 29 - The axial skeleton is to the appendicular skeleton...Ch. 29 - Prob. 3MCQCh. 29 - Prob. 4MCQCh. 29 - Prob. 5MCQCh. 29 - Prob. 6MCQCh. 29 - Prob. 1WIOCh. 29 - Prob. 2WIOCh. 29 - Prob. 3WIOCh. 29 - Prob. 4WIOCh. 29 - Prob. 5WIOCh. 29 - Prob. 6WIOCh. 29 - Describe four muscle proteins and their functions.Ch. 29 - Prob. 8WIOCh. 29 - Prob. 9WIOCh. 29 - Prob. 10WIOCh. 29 - Write the sequence of events that leads to a...Ch. 29 - Prob. 12WIOCh. 29 - Refer to figure 29.24 and the chapter content to...Ch. 29 - 3. Add exercise to the concept map in at least...
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- Different mutations in the WDR62 gene that inactivate gene function were found in the genomes of many different people with microcephaly. This information provided strong support for the idea that the WDR62 gene mutation causes microcephaly. The human genome sequence identified WDR62 as one of the approximately 27,000 genes in the human genome. What information about the function of WDR62 do you think was learned originally from the DNA sequence of the normal human genome? What additional information was provided by identification of WDR62 as the microcephaly disease gene?arrow_forwardThe figure shows the position of two of these mutations a and b. The nucleotides are altered in these 2 different swo-1 mutant alleles. Use the genetic table to describe any AA changes.Name the type of mutation and describe its effect on swo-1 mRNA and protein for each of the mutations. 3. The swo-1 a mutation (insertion between C and G). 4. The swo-1 b mutation (C-to-T mutation for indicated C). 5. The swo-1 a mutation leads to worms with more body wall muscle, whereas worms with the swo-1 b mutation are not able to move. Based on these phenotypes and the findings from questions 3 and 4, describe the role thewild-type version of this protein plays in muscle function.arrow_forwardA 2500 bp region of the human genome encodes two genes. One of the genes encodes a protein of 600 amino acids and the other gene encodes a protein of 280 amino acids. The mRNA sequences of the two genes do not contain any of the same nucleotide sequences (i.e. they do not overlap). How is this possible? Fully explain your answer.arrow_forward
- An example sequence corresponds to human sickle cell beta-globin mRNA and that this disease results from a point mutation in the β globin gene. In the following section, you will compare sickle cell and normal β globin sequences to reveal the nature of the sickle cell mutation at the protein level. To do this you need to find at least one sequence representing the normal beta globin gene. Open a new window and visit the NCBI home page(http://www.ncbi.nlm.nih.gov) and select “Nucleotide” from the drop menu associated with the top search box. Then enter the search term: HBB . Note that lots of irrelevant results are returned so let's apply some “Filters” (available by clicking in the left-hand sidebar) to focus on RefSeq entries for Homo sapiens. Remember that we are after mRNA so we can compare to the mRNA sequence from part 1 above. QUESTION #1: What is the ACCESSION number of the “Homo sapiens hemoglobin, beta (HBB), mRNA” entry? NOTE: Boolean operators (NOT, AND, OR) as…arrow_forwardHere is some information about the sequences: There are two images given; one with sequences and the other with a figure. All these sequences, “SEQUENCE_21” to “SEQUENCE_27” are in the same subfamily or “clade” of a large phylogenetic alignment of all Rab proteins in these three species (see “Image with a figure” for a full view of gene family in humans, plants and yeast, see the “D” branch towards the bottom of the tree in Figure). “SEQUENCE_28” is a different Rab protein (actually it is the Rab39 protein at the bottom of the tree). “SEQUENCE_21” is from yeast. “SEQUENCE_22” to “SEQUENCE_25” are from the plant, Arabidopsis. “SEQUENCE_26” and “SEQUENCE_27” are from humans. Question: Based on the information above, what can you speculate about the possible evolution of the genes that “SEQUENCE_21” to “SEQUENCE_27” represent?arrow_forwardIn relation to central dogma of molecular biology answer the following questions: The length of a particular gene in human DNA, measured from the start site for transcription to the end of the protein-coding region, is 10,000 nucleotides, whereas the length of the mRNA produced from this gene is 4000 nucleotides. What is the most likely reason for this difference?arrow_forward
- There are five substitution mutations in the dark-colored mutant Mc1r gene. Compare the DNA sequence of the light-colored wild-type Mc1r gene with the DNA sequence of the dark-colored mutant Mc1r gene. Indicate the locations of the five mutations by changing the font color to YELLOW for the five single DNA nucleotides that are mutated in the mutant Mc1r gene table. Using the information in the introduction, determine whether each of these mutations is a silent, missense, or nonsense mutation. Using the mutant Mc1r gene data, fill in the columns (including DNA, mRNA, and amino acid) in gene table 2 that contain a silent mutation with BLUE. Likewise, fill in the columns that contain a missense mutation with RED. Shade any columns that contain nonsense mutations with GREEN. Then Of the five mutations you identified in the mutant Mc1r gene, how many are: substitutions insertions deletions (Enter a number on each line.) 2. Of the five mutations…arrow_forwardHere is some information about the sequences: All these sequences, “SEQUENCE_21” to “SEQUENCE_27” are in the same subfamily or “clade” of a large phylogenetic alignment of all Rab proteins in these three species (see “Figure 1.pdf” for a full view of gene family in humans, plants and yeast, see the “D” branch towards the bottom of the tree in Figure 1). “SEQUENCE_28” is a different Rab protein (actually it is the Rab39 protein at the bottom of the tree). “SEQUENCE_21” is from yeast. “SEQUENCE_22” to “SEQUENCE_25” are from the plant, Arabidopsis. “SEQUENCE_26” and “SEQUENCE_27” are from humans. Question: Based on the information above, what can you speculate about the possible evolution of the genes that “SEQUENCE_21” to “SEQUENCE_27” represent? (write 5 points at least).arrow_forwardThe figure below shows the introns and exons found in gene X. The size of each exon and intron is shown as well. A study on this organism found that two mature mRNA molecules are produced for this gene. One is 867 nucleotides in length, and the other is 685 nucleotides in length. Name the process responsible for producing this variation. Also explain how these 867 and 685 nucleotide fragments were produced by referring to the information provided. Hint: This organism produces a poly-A tail of 150 nucleotides.arrow_forward
- The figure below shows the introns and exons found in gene X. The size of each exon and intron is shown as well. A study on this organism found that two mature mRNA molecules are produced for this gene. One is 457 nucleotides in length, and the other is 439 nucleotides in length. Name the process responsible for producing this variation. Also explain how these 457 and 439 nucleotide fragments were produced by referring to the information provided. Hint: This organism produces a poly-A tail of 120 nucleotides. 99 62 120 84 102 27 117 Gene X E1 11 E2 12 ЕЗ 13 E4 Exon (E) Intron (I)arrow_forwardThe figure below shows the introns and exons found in gene X. The size of each exon and intron is shown as well. A study on this organism found that two mature MRNA molecules are produced for this gene. One is 457 nucleotides in length, and the other is 439 nucleotides in length. Name the process responsible for producing this variation. Also explain how these 457 and 439 nucleotide fragments were produced by referring to the information provided. Hint: This organism produces a poly-A tail of 120 nucleotides. 99 62 120 84 102 27 117 Gene X E1 в в 11 E2 12 E4 Exon (E) Intron (1)arrow_forwardThe abundance of three mRNA transcripts, transcripts A, B, and C, was measured by real-time PCR. The average CT values were 14.6, 20.2, and 10.5 for transcripts A, B, and C, respectively. Determine the relative order of abundance of the transcripts. Name one technique that could be used to confirm that the order of abundance at the mRNA transcript level is reflected at the protein level.arrow_forward
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