(a)
To determine: The reason as to why alanine predominantly occurs as zwitterion rather than completely uncharged at its pI.
Introduction:
Alanine is an amino acid used in the biosynthesis of polypeptides or proteins. It consists of α-amino group and α-carboxylic group. The side chain of alanine consists of methyl group. This makes alanine a non-polar and an aliphatic amino acid.
(b)
To determine: The fraction of alanine that is present in completely uncharged form at its pI.
Introduction:
The fraction of alanine that is present in completely uncharged form at its pI can be calculated through Henderson-Hasselbalch equation, which is as follows:
Here, pH is the concentration of hydrogen ion.
pKa is the equilibrium constant.
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Chapter 3 Solutions
Lehninger Principles of Biochemistry (Instructor's)
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