Concept explainers
(a1)
To determine: Equilibrium equations for three ionizations of histidine and assign pKa value for each ionization state.
Introduction: Amino acids are the monomer units of proteins. These are basically organic compounds consisting of a carboxylic group (-COOH) and an amino group (-NH2). Along with these
(a2)
To draw: Histidine structure in each ionization state.
Introduction: Histidine is a basic amino acid with lysine and arginine. Histidine consists of three ionizable groups. These are α-amino group, α-
(a3)
To determine: The net charge on histidine molecule in each ionization state.
Introduction:
Histidine is a basic amino acid along with lysine and arginine. Histidine consists of three ionizable groups. These are α-amino group, α-carboxylic acid group, and side chain amino group.
(b)
To draw: The structures of histidine at pH 1, 4, 8, and 12.
Introduction:
pH is defined as the negative of base 10 logarithm of hydrogen ion concentration. It is a scale to determine the nature of an aqueous solution; acidic or alkaline.
(c1)
To determine: The net charge of histidine at pH 1, 4, 8, and 12.
Introduction:
pH is defined as the negative of base 10 logarithm of hydrogen ion concentration. It is a scale to determine the nature of an aqueous solution; acidic or alkaline.
(c2)
To determine: Whether histidine would migrate towards anode or cathode in an electric field for each pH.
Introduction:
pH is defined as the negative of base 10 logarithm of hydrogen ion concentration. It is a scale to determine the nature of an aqueous solution; acidic or alkaline.
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Chapter 3 Solutions
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