BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
9th Edition
ISBN: 9781319425746
Author: BERG
Publisher: MAC HIGHER
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Chapter 33, Problem 12P
Interpretation Introduction
Interpretation:
The sequence of mRNA molecule that can be regulated by given miRNA should be determined.
Concept introduction:
miRNAs (microRNA) are the small RNA molecules, that are non-coding in nature. They can be found in various plants, animals, and viral species. The functions of miRNAs are RNA silencing and gene regulation at the post-transcriptional level.
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An extra piece. In one type of mutation leading to a form of
thalassemia, the mutation of a single base (G to A) generates a new 3'
3' splice site (blue in the illustration below) akin to the normal one
(yellow) but farther upstream.
Normal 3' end
of intron
5' CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3'
5' CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3'
What is the amino acid sequence of the extra segment of protein
synthesized in a thalassemic patient having a mutation leading to
aberrant splicing? The reading frame after the splice site begins with
TCT.
Chapter 33 Solutions
BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
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