Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 44, Problem 12TYK
Summary Introduction

To review:

The impact of carbon monoxide (CO), a component of cigarette smoke that binds irreversibly to the hemoglobin, on a smoker's health.

Introduction:

In the human circulatory system, erythrocytes are the oxygen (O2) carriers of the blood. They carry oxygen from the lungs to the rest of the body parts. Erythrocytes are the blood cells that are flattened, disc-like, and biconcave in shape, which provides flexibility to the cells: 8 µm (micrometers) in diameter and 2 µm thick. Hemoglobin is the protein that carries oxygen and gives red color to the erythrocytes.

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. Nicotine, one of the components of cigarettes, slows cilia" lining the respiratory tract, causes blood vessels to con­strict, and increases heart rate. Another component of cigarette smoke is carbon monoxide. As you have read, carbon monoxide competes with oxygen for binding sites on the hemoglobin molecule found in red blood cells. Analyse the data presented, and describe the potential dangers associated with smoking.
What is the role of the heme prosthetic group in hemoglobin? A. The heme group coordinates the subunits of hemoglobin. B. The heme group binds one molecule of oxygen in the center of the hemoglobin protein. C. The heme group binds a molecule of oxygen for each subunit of hemoglobin. D. The iron atom in the heme group is needed to irreversibly bind oxygen.
Which of the following is true about the proximal histidine of hemoglobin? A. It forms a hydrogen bond with bound oxygen. B. It is bonded to the Fe2+ atom coordinated by heme C. It binds oxygen D. It is not consumed in myoglobin
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