BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
9th Edition
ISBN: 9781319425746
Author: BERG
Publisher: MAC HIGHER
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Chapter 5, Problem 21P
Interpretation Introduction
Interpretation:
The reason corresponding to the given survey that the person B possesses no symptoms of drugs is to be stated. The possible defects in the other given people are to be stated.
Concept introduction:
The basic unit of heredity which is made up of DNA segments is known as gene.
The process of duplicating a specific DNA segment into a RNA segment with the help of an enzyme is known as transcription. The process of synthesizing proteins inside the cytoplasm after the completion of transcription is known as translation.
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A series of people are found to have difficulty eliminating certain types of drugs from their bloodstreams. The problem has been linked to a gene X, which encodes an enzyme Y. Six people were tested with the use of various techniques of molecular biology. Person A is a normal control, person B is asymptomatic but some of his children have the metabolic problem, and persons C through F display the trait. Tissue samples from each person were obtained. Southern analysis was performed on the DNA after digestion with the restriction enzyme Hin dIII. Northern analysis of mRNA also was done. In both types of analysis, the gels were probed with labeled X cDNA. Finally, a western blot with an enzyme-linked monoclonal antibody was used to test for the presence of protein Y. The results are shown here. Why is person B without symptoms? Suggest possible defects in the other people.
A 30 - year - old woman was undergoing therapy for b-thalassemia,a recessive trait caused by absence of or reduced synthesis ofthe hemoglobin b chain, a subunit of the oxygen-carrying moleculein red blood cells. In this condition, red blood cells are rapidlydestroyed, freeing a large amount of iron, which is deposited in tissuesand organs. The blood transfusions the patient had received every twoor three weeks since the age of 7 to stave off anemia were furtheraggravating iron buildup. Her major organs were showing damage, andshe was in danger of death from cardiac disease. Her physician suggestedthat she consider undergoing a hematopoietic (bone marrow)stem cell transplant (HSCT). Since these stem cells give rise to redblood cells, such a transplant could potentially restore her health. Whilethis might seem like an easy decision, it is not. Advanced cases havea high risk (almost 30 percent) for transplantation-related death. At thispoint, the woman is faced with a difficult and…
A 30 - year - old woman was undergoing therapy for b-thalassemia,a recessive trait caused by absence of or reduced synthesis ofthe hemoglobin b chain, a subunit of the oxygen-carrying moleculein red blood cells. In this condition, red blood cells are rapidlydestroyed, freeing a large amount of iron, which is deposited in tissuesand organs. The blood transfusions the patient had received every twoor three weeks since the age of 7 to stave off anemia were furtheraggravating iron buildup. Her major organs were showing damage, andshe was in danger of death from cardiac disease. Her physician suggestedthat she consider undergoing a hematopoietic (bone marrow)stem cell transplant (HSCT). Since these stem cells give rise to redblood cells, such a transplant could potentially restore her health. Whilethis might seem like an easy decision, it is not. Advanced cases havea high risk (almost 30 percent) for transplantation-related death. At thispoint, the woman is faced with a difficult and…
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BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
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