Concept explainers
Based on previous family studies, an autosomal recessive disease with alleles A and a is suspected to be linked to an RFLP marker. The RFLP marker has four alleles,
a. What is the most likely arrangement of synthesis alleles for the RFLP and the disease gene in
b. Is there any evidence of recombination in this pedigree? If so, identify the recombinant individuals and illustrate the recombination that has occurred.
c. Based on your analysis, what is the recombination frequency in this family? Explain how you obtained your answer.
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GENETIC ANALYSIS: INTEGRATED - ACCESS
- a. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? Explain your reasoning. b. Based your answer to part a, give the most likely genotypes for all family members in the pedigree.arrow_forwardPlease consider the pedigree below. There are no cases of false paternity. I II III IV в 1 a. Which individual/s definitely has/have Bombay phenotype in the descendants of I-1 and I-2? b. What are the genotypes of individuals II-2 and III-2 at the AB0 and H loci? Please label your answers a and b, Il-2: and Ill-2:.arrow_forwardHelp me create a pedigree of this information: Pedigree analysis: Generation 1: Normal parents (AA x AA) Generation 2: Carrier parents (AA x AS) Generation 3: Affected child (AS x AS) Generation 4: Affected grandchild (SS) This pedigree has two normal parents in the first generation. Second generation carriers carry the sickle cell trait from one parent. The disease is 25% more likely to be inherited in the third generation if both parents have the 'S' allele. If both parents have the 'S' allele, their children will have sickle cell anemia in the fourth generationarrow_forward
- Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f What is the genotype of individual #13? A) ff B) FF C) Ff D) it is impossible to tellarrow_forwardBelow is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forwardA SNP marker is found linked to the cystic fibrosis gene. Cystic fibrosis is an autosomal recessive disease. A couple plans to have children together and both are carriers for the cystic fibrosis gene but do not have the disease themselves. They are both A1/A2 at the SNP and the A2 allele is linked with the allele causing cystic fibrosis. Assuming no crossing over between the SNP and the disease gene, what genotypes in the offspring could result that would cause cystic fibrosis? O A1-cf, A1 - cf O A2-cf, A2 - cf O A1 - CF, A1 - CF O A1 - CF, A2 - cfarrow_forward
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- Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.arrow_forwardThe pedigree below shows the inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cM to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below the pedigree. 13 12 ? 12 A 22 32 32 B a. What is the probability that individual A will develop the disease? Explain you reasoning using an illustration of how this occurs. b. What is the probability that individual B will develop the disease? Explain your reasoning.arrow_forwardPedigree analysis is often used to determine mode of inheritance (dominant or recessive, for example). Be sure to read the "Tips for Pedigree Analysis" in Figure 14.15 in 34. your text. Consider the following pedigree for the trait albinism (lack of skin pigmentation) in three generations of a family. (Solid symbols represent individuals with albinism.) Complete the unlabeled pedigree by indicating the genotypes for all involved. From your knowledge of Mendelian inheritance, answer the questions that follow. a. Is this trait caused by a dominant or recessive allele? What is the evidence for your response?arrow_forward
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