Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 5, Problem 8QP
Clubfoot is a common congenital birth defect. This defect is caused by a number of genes but appears to be
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In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A).
What is the genotype of someone who has cystic fibrosis?
What are the two different genotypes that a healthy person could have?
If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
Total fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females.
Predict the TRC for each of the following individuals:
Genotype
Male
Female
AABBCCDD
AabbccDd
AaBBCcDD
aaBbCCDd
A. Write the genotypes of parents who are heterozygous for all four genes.
B. Write the genotype of their child who has the maximum number of active alleles possible.
C. What are the TRCs for the parents?
D. What is the TRC of the child from B (assume male)?…
Total fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females.
Predict the TRC for each of the following individuals:
Genotype
Male
Female
AABBCCDD
AabbccDd
AaBBCcDD
aaBbCCDd
Chapter 5 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 5.5 - Prob. 1GRCh. 5.5 - What are the possible advantages or disadvantages...Ch. 5 - After hearing this information, should Sue and Tim...Ch. 5 - Can cleft lip be surgically corrected? Sue and Tim...Ch. 5 - If the child showed a cleft lip through ultrasound...Ch. 5 - Describe why continuous variation is common in...Ch. 5 - The text outlines some of the problems Frederick...Ch. 5 - What role might environment have played in causing...Ch. 5 - Do you think Frederick Williams experiment would...Ch. 5 - As it turned out, one of the tallest Potsdam...
Ch. 5 - Describe why there is a fundamental difference...Ch. 5 - Sunflowers with flowers 10 cm in diameter are...Ch. 5 - Clubfoot is a common congenital birth defect. This...Ch. 5 - Define genetic variance.Ch. 5 - Define environmental variance.Ch. 5 - How is heritability related to genetic and...Ch. 5 - Why are relatives used in the calculation of...Ch. 5 - If there is no genetic variation within a...Ch. 5 - Can conjoined (Siamese) twins be dizygotic twins...Ch. 5 - Dizygotic twins: a. are as closely related as...Ch. 5 - Why are monozygotic twins who are reared apart so...Ch. 5 - Monozygotic (MZ) twins have a concordance value of...Ch. 5 - If monozygotic twins show complete concordance for...Ch. 5 - Researchers set up an obesity study in which MZ...Ch. 5 - What does the ob gene code for? How does it work?...Ch. 5 - What is the importance of the comparison of traits...Ch. 5 - Height in humans is controlled by the additive...Ch. 5 - If diseases such as cardiovascular disease...Ch. 5 - Prob. 24QPCh. 5 - Prob. 25QPCh. 5 - Suppose that a team of researchers analyzes the...
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forward
- A study of three generations in a family of a male colleague of the authors indicated that many of the man's blood relatives had died of cardiovascular accidents and coronary heart disease. Others died of other causes but were affected by high blood pressure. What are the implications of this information for the man in question? b. What information and help might a genetic counselor provide?arrow_forwardSkin color is one of the traits in a human which is determined by polygenic inheritance system because it is possibly involving as many as 9 genes. To make this simple, let us consider the influence of 2 genes: A and B., where dark skin color is dominant. Suppose a man who is AABb marries a woman who is Aabb, what would be the genotypes of their children. Prove your answer by using a Punnet Square.arrow_forwardWhich of the following statements describes the multifactual inheritance in genetics? A. One locus is associated with different traits. B. One locus is associated with variable phenotypes of a trait. C. Several loci are associated with the trait.arrow_forward
- Skin color in humans is determined by polygenic inheritance, which means the more dominant alleles there are, the darker the skin color will be. A medium-toned skinned woman (AaBb) has a child with another medium-toned skinned man (AaBb). What is the probability of them having a very dark-toned skinned child? (Hint: the genotype is homozygous dominant)arrow_forwardIndividuals, such as Ryan Clark and Geno Atkins, heterozygous for the sickle cell allele show effects of the allele under some circumstances (refer to the linked article and Mendelian patterns of inheritance in your text). Explain in terms of gene expression. http://www.nfl.com/news/story/0ap3000000714754/article/coleman-unsure-on-denver-game-due-to-sickle-cell-traitarrow_forwardBelow is a pedigree of a human genetic disease in which solid color indicates affected individuals. Assume that the disease is caused by a gene that can have the alleles A or a. a) Based on this pedigree, what is the most likely mode of inheritance? b) What is/are the possible genotype/s of person 1? c) What is/are the possible genotype (s) of person 4 ? Explain your answers.arrow_forward
- Farmer Brown had two hogs, Olga and Hank. Olga and Hank were normal, healthy hogs, but whenever Farmer Brown crossed them, a few of the piglets had cleft palates. Assuming a simple autosomal basis for cleft palate, what are the genotypes of Olga and Hank, and about what proportion of the piglets are born with a cleft palate?arrow_forwardIn humans, alkaptonuria is a metabolic disorder in which affected persons produce black urine. Alkaptonouria results from an allele (a) that is recessive to the allele for normal metabolism (A). Alana has a normal metabolism, but her brother has alkaptonouria. Alana’s father has alkaptonuria. Give the genotypes of Alana _______, her mother________, her father_______, and her brother______. If Alana’s parents have another child, what is the probability that the child will have alkaptonuria?_____ If Alana marries a man with alkatonuria, what is the probability that their first child will have black urine? _______ What is the probability that 3 of their children will have black urine?__________ If Alana marries a man that does not have alkatonuria, but has a mother that does, then what is the probability that their first child will have black urine? _______ 3 children in a row? ___________arrow_forwardAlbinism is the absence of pigment throughout the body. Animals with albinism have white fur and reddish eyes. Albinism is inherited as a recessive trait, so animals with two a alleles have albinism, whereas animals with at least one dominant A allele have normal coloring. Using the Punnett square below, determine the probability of two albino parents (with aa genotypes) producing a child with albinism.arrow_forward
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