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Clubfoot is a common congenital birth defect. This defect is caused by a number of genes but appears to be phenotypically distributed in a noncontinuous fashion. Geneticists use the threshold model to explain the occurrence of this defect. Explain this model. Explain predisposition to the defect in an individual who has a genotypic liability above the threshold versus an individual who has a liability below the threshold.

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 5, Problem 8QP
Textbook Problem
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Clubfoot is a common congenital birth defect. This defect is caused by a number of genes but appears to be phenotypically distributed in a noncontinuous fashion. Geneticists use the threshold model to explain the occurrence of this defect. Explain this model. Explain predisposition to the defect in an individual who has a genotypic liability above the threshold versus an individual who has a liability below the threshold.

Summary Introduction

To explain: The threshold model for the occurrence of a common congenital birth defect called clubfoot.

Introduction: Clubfoot is a common congenital birth defect, which is caused by a number of genes (polygenic inheritance), but it is phenotypically distributed in a noncontinuous fashion. The occurrence of this defect is explained by the threshold model.

Explanation of Solution

The distribution of clubfoot resembles the inheritance of the single-gene trait, but in fact, it is a complex trait that is controlled by several genes. The threshold model explains the discontinuous distribution of the clubfoot defect. It says that the distribution of risks for clubfoot is dependent on the degree of relatedness between the relatives. The risk for disorder decreases as the degree of relatedness decreases...

Summary Introduction

To explain: The predisposition to the clubfoot defect when an individual has genetic liability above the threshold versus when an individual has a liability below the threshold.

Introduction: Clubfoot is a common congenital birth defect, which is caused by a number of genes (polygenic inheritance), but it is phenotypically distributed in a noncontinuous fashion. The occurrence of this defect is explained by the threshold model.

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