ESSENTIALS OF GENETICS-MODIFIED ACCESS
ESSENTIALS OF GENETICS-MODIFIED ACCESS
9th Edition
ISBN: 9780134190006
Author: KLUG
Publisher: PEARSON
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Chapter 6, Problem 12PDQ

Human adult hemoglobin is a tetramer containing two alpha (α) and two beta (β) polypeptide chains. The a gene cluster on chromosome 16 and the β gene cluster on chromosome 11 share amino acid similarities such that 61 of the amino acids of the α-globin polypeptide (141 amino acids long) are shared in identical sequence with the β-globin polypeptide (146 amino acids long). How might one explain the existence of two polypeptides with partially shared function and structure on two different chromosomes? Include in your answer a link to Ohno's hypothesis regarding the origin of new genes during evolution.

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