Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 6, Problem 22P
A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-μg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11.
Are there any advantages to using a common medium versus using different media for performing the susceptibility tests with regard to standardization of results across laboratories?
Table 6.11 Mean zone diameters with 30-μg netilmicin disks tested in nine separate laboratories
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A nine-laboratory cooperative study was performed toevaluate quality control for susceptibility tests with 30-μgnetilmicin disks . Each laboratory tested three standardcontrol strains on a different lot of Mueller-Hinton agar, with150 tests performed per laboratory. For protocol control,each laboratory also performed 15 additional tests on eachof the control strains using the same lot of Mueller-Hintonagar across laboratories. The mean zone diameters for eachof the nine laboratories are given in the image.Problem a ) Provide a point and interval estimate (95% CI) forthe mean zone diameter across laboratories for each typeof control strain, assuming each laboratory uses differentmedia to perform the susceptibility tests.Problem b ) Answer Problem a assuming each laboratory usesa common medium to perform the susceptibility tests.Problem c ) Provide a point and interval estimate (95% CI) for theinterlaboratory standard deviation of mean zone diametersfor each type of control strain,…
Five samples of a ferrous-type substance were used to determine if there is a difference between a laboratory chemical analysis and an X-ray fluorescence analysis of the iron content. Each sample was split into two subsamples and the two types of analysis were applied, with the accompanying results. Assuming that the populations are normal, test at the 0.10 level of significance whether the two methods of analysis give, on the average, the same result.
A researcher was interested in comparing the amount of time (in hours) spent working out by women and by men. Independent simple random samples of 14 women and 17 men were selected, and each person was asked how many hours he or she worked out during the previous week. The summary statistics are as follows. Test the claim, using a 99% CI, that the mean amount of time spent working out by women is smaller than the mean amount of time spent by men. Assume the variables are approximately normally distributed.
Mean
Std dev
Sample size
Women
17.8 hrs
2.9 hr
24
Men
19.5 hrs
6.2 hrs
27
Chapter 6 Solutions
Fundamentals of Biostatistics
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