EBK HUMAN PHYSIOLOGY
15th Edition
ISBN: 8220106796238
Author: Fox
Publisher: YUZU
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Chapter 6, Problem 36RA
Summary Introduction
To analyze:
The following:
The equilibrium potential for potassium or K+ (EK) when its extracellular concentration rises from 5mM (millimolar) to 10mM.
Whether the change is a depolarization or a hyperpolarization compared to normal EK.
Introduction:
The intracellular and extracellular fluids have different inorganic ions and they are maintained at specific concentration. When the concentration is changed, an action potential is produced by each ion across the plasma membrane and is known as membrane potential. The membrane potential is generally determined by K+ ion concentration across the membrane because the plasma membrane is more permeable to K+ ions than any other ions.
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If a particular neuron has an intracellular Chloride concentration of 154.3 mM, an extracellular Chloride concentration of 163.2 mM, and a membrane potential of -54.1, what is the net driving force (in mV) acting upon Chloride?
Table Q1(a) shows typical values for the intracellular and extracellular
concentrations of the major ion species (in millimoles per litre) for frog skeletal
muscle.
Table Q1(a)
Permeability (cm/s)
2 x 10-8
2х 10
Ions
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Extracellular
Na*
12
145
K+
155
4
4
120
4 x 106
By referring to Table Q1(a), compute the equilibrium resting potential for this
membrane by assuming the room temperature is 20° C. Given the Boltzman's
constant, k = 1.38 x 1023 J/K and an electronic charge, q = 1.602 x 10-19 C.
Given that the extracellular concentration of Cl- is approximately 120 mM, what is the intracellular concentration if the Nernst
potential for Cl- is 39 mV. (T=298 K, R=1.987 cal/K·mol, F=23,062 cal/mol·V)
Chapter 6 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 6 - Describe the distribution of fluid in the body.Ch. 6 - Describe the composition of the extracellular...Ch. 6 - List the subcategories of passive transport and...Ch. 6 - Explain what is meant by simple diffusion and list...Ch. 6 - Prob. 4CPCh. 6 - Prob. 5CPCh. 6 - Explain how the body detects changes in the...Ch. 6 - Prob. 7aCPCh. 6 - Prob. 7bCPCh. 6 - Prob. 7cCP
Ch. 6 - Prob. 8CPCh. 6 - Prob. 9aCPCh. 6 - Prob. 9bCPCh. 6 - Explain the relationship of the resting membrane...Ch. 6 - Prob. 10bCPCh. 6 - Prob. 11CPCh. 6 - Prob. 12CPCh. 6 - The movement of water across a plasma membrane...Ch. 6 - Which of these statements about the facilitated...Ch. 6 - Prob. 3RACh. 6 - Prob. 4RACh. 6 - Blood plasma has an osmolality of about 300 mOsm....Ch. 6 - Prob. 6RACh. 6 - The most important diffusible ion in the...Ch. 6 - Prob. 8RACh. 6 - Prob. 9RACh. 6 - Prob. 10RACh. 6 - Prob. 11RACh. 6 - Prob. 12RACh. 6 - Prob. 13RACh. 6 - Prob. 14RACh. 6 - Which of the following questions regarding second...Ch. 6 - Prob. 16RACh. 6 - Prob. 17RACh. 6 - Compare the resting membrane potential of a neuron...Ch. 6 - Prob. 19RACh. 6 - Prob. 20RACh. 6 - Prob. 21RACh. 6 - Prob. 22RACh. 6 - Using the principles of osmosis, explain why...Ch. 6 - Prob. 24RACh. 6 - Prob. 25RACh. 6 - Prob. 26RACh. 6 - Prob. 27RACh. 6 - Prob. 28RACh. 6 - Prob. 29RACh. 6 - Prob. 30RACh. 6 - Using only the information in this chapter,...Ch. 6 - Prob. 32RACh. 6 - Prob. 33RACh. 6 - Suppose a semipermeable membrane separates two...Ch. 6 - Prob. 35RACh. 6 - Prob. 36RACh. 6 - Use the Nernst equation and the ion concentration...
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- Calculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). (a)Membrane permeable only to Na+.arrow_forwardCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50 M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane equally permeable to both ions.arrow_forwardWhich factors determine the resting membrane potential? Explain why the resting membrane potential is never really the value calculate by the Nernst equation for the potassium equilibrium potential. comments : please answer me in a correct way to hence my knowledge and for my better understandingarrow_forward
- The ion flows across neuronal membranes at rest and duringan action potential do not significantly change bulk ionconcentrations, except for that of Ca2+ ions. Resting Ca2+ ionconcentrations in cells are usually about 10–7 M, and Ca2+ ionsexert physiological effects at concentrations of perhaps 10–5 M.Explain why relative changes of intracellular [Ca2+] are muchgreater than for, say, [Na+] (12–50 mM).arrow_forwardA cell has an actual membrane potential (Em) at rest of -75mV. The equilibrium potential for Na+ is +120mV and the equilibrium potential for K+ is -95mV. Calculate the net driving force for Na+ in mV.arrow_forwardAt the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table), (1) calculate the driving force (in mV) that acts on K+ ions and (2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)arrow_forward
- The normal concentrations for intracellular and extracellular potassium in a neuron are [K+]in = 150 mM and [K+]out = 5 mM, respectively. Due to an electrolyte imbalance, a patient has the following intracellular and extracellular concentrations of potassium: [K+]in = 140 mM and [K+]out =2 mM. Using the Nernst equation (Chapter 4), calculate the equilibrium potential for potassium in the cells with normal K+ distributions and of the diseased patient. Refer back to Question #1. Will it be easier or more difficult to generate an action potential in the diseased neuron as compared to the normal neuron? Why?arrow_forwardIntracellular potentials are on the order of -100mV, whereas extracellular potentials are OmV. Assuming these values, answer the following questions. (a) What is the electric potential energy of a chloride ion (CI-) inside a cell? (b) What about outside the cell? (c) What is the probability of finding a Cl- inside the cell relative to finding it outside the cell? Assume that T=310K. P(inside) P(outside) (d) If the concentration of Cl- outside the cell is 100mM, what is the expected concentration inside the cell?arrow_forward(a) Table Q1(a) shows typical values for the intracellular and extracellular concentrations of the major ion species (in millimoles per litre) for frog skeletal Q1 muscle. Table Q1(a) Permeability (cm/s) 2 x 10-8 2 x 106 4 x 10-6 Ions Intracellular Extracellular Na* 12 145 K* 155 4 4 120 By referring to Table Q1(a), compute the equilibrium resting potential for this membrane by assuming the room temperature is 20° C. Given the Boltzman's constant, k= 1.38 x 1023 J/K and an electronic charge, q = 1.602 x 1019 C.arrow_forward
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