GENETIC ANALYSIS: INTEGRATED - ACCESS
GENETIC ANALYSIS: INTEGRATED - ACCESS
3rd Edition
ISBN: 9780135349298
Author: Sanders
Publisher: PEARSON
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Chapter 7, Problem 33P
Summary Introduction

To analyze:

Analyze the effect on DNA replication if mutation of DNA pol III loses each of the following activities,

  1. 5'3' polymerase activity.

  2. 3'5' exonuclease activity.

Introduction:

DNA replication is one of the basic and important processes that occurs within the cell in which a double stranded DNA molecule is copied to produce two identical DNA molecules. In prokaryotes, the replication of DNA is bidirectional, which is, processing from a single point of origin of replication to both directions, and the series of proteins and enzymes are involved in the replication mechanism.

One of the important enzymes in the DNA replication mechanism is DNA polymerase III. The main replicative enzyme is DNA polymerase III. It synthesizes a new DNA strand in 5'3' direction.

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Students have asked these similar questions
what if a mutation resulted in the enzyme DNA polymerase III being non-functional? How would that affect DNA replication
What would be the effect on DNA replication of mutations that destroyed each of the following activities in the DNA polymerase I? 3' - 5' exonuclease activity 5' -3' exonuclease activity 5' -3' polymerase activity
During DNA replication, the two new daughter DNA strands have to be made at the same time in the same direction by DNA polymerase III. How is this accomplished?

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GENETIC ANALYSIS: INTEGRATED - ACCESS

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