Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 8, Problem 8.6CC
You are studying the energetics of transport of the amino acid aspartic acid, whose side chain can exist in the nonionized neutral state (—COOH) or the ionized, negatively charged state (—COO–). To calculate the ΔG of transport into a cell, why would you need to know the ionization state of the side chain?
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Chapter 8 Solutions
Becker's World of the Cell (9th Edition)
Ch. 8 - What is the difference between the concentration...Ch. 8 - Prob. 8.2CCCh. 8 - A researcher is studying a fern that is shown to...Ch. 8 - How are carrier proteins and channel proteins...Ch. 8 - How would you determine whether a specific...Ch. 8 - Both the Na+/glucose symporter and the Na+/K+ pump...Ch. 8 - You are studying the energetics of transport of...Ch. 8 - True or False? Indicate whether each of the...Ch. 8 - Telling Them Apart. From the following list of...Ch. 8 - Mechanisms of Transport. For each of the following...
Ch. 8 - Prob. 8.4PSCh. 8 - Prob. 8.5PSCh. 8 - Prob. 8.6PSCh. 8 - QUANTITATIVE Sodium Ion Transport. A marine...Ch. 8 - Prob. 8.8PSCh. 8 - Prob. 8.9PSCh. 8 - QUANTITATIVE The Calcium Pump of the Sarcoplasmic...Ch. 8 - Inverted Vesicles. An important advance in...Ch. 8 - Ouabain Inhibition. Ouabain is a specific...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The K+ channel is an example of a transmembrane protein (a protein that spans the phospholipid bilayer of the plasma membrane). What types of amino acids are likely to be found (a) lining the channel through which K+ passes, (b) in contact with the hydrophobic core of the phospholipid bilayer con- taining fatty acyl groups, (c) in the cytosolic domain of the protein, and (d) in the extracellular domain of the protein?arrow_forwardUniporters and ion channels support facilitated transport across cellular membranes. Although both are examples of facilitated transport, the rates of ion movement via an ion channel are roughly 104- to 105-fold faster than the rates of molecule movement via a uniporter. What key mechanistic difference results in this large difference in transport rate? What contribution to free energy (ΔG) determines the direction of transport?arrow_forwardOf the following cell membrane lipids, which one prefers to reside in the inner leaflet (or inner half) of the membrane bilayer, AND has an overall neutral charge at physiological pH (7.4)? a) PE (phosphatidylethanolamine) is inner-leaflet with an overall neutral charge at pH 7.4 b) SM (sphinogomyelin) is inner-leaflet with an overall neutral charge at pH 7.4 c) PS (phosephatidylserine) is inner-leaflet with an overall neutral charge at pH 7.4 d) PC (phosphatidylcholine) is inner-leaflet with an overall neutral charge at pH 7.4arrow_forward
- Explain how can one predict the number of transmembrane domains (TM helices) in an integral membrane protein. Note: For the above question, I only seek for an original answer no more than six sentences.arrow_forwardProteins that span the biological membrane bilayers often contain α-helices and b-barrels. (a) Given that the insides of membranes are highly hydrophobic, predict what type of amino acyl residues would be found in a single alpha-helix that is spanning a membrane – draw a diagram to illustrate the arrangement of the R-groups within the membrane bilayer. (b) Using a drawing, illustrate the R-group arrangement in the membrane-spanning region of a channel protein for water transport if the channel was made of: six alpha-helices six beta-strandsarrow_forwardA simple enzyme reaction can be described by the equation e + s ↔ es ↔ e + p, where e is the enzyme, s the substrate, p the product, and es the enzyme– substrate complex.Write a corresponding equation describing the workings of a transporter (T) that mediates the transport of a solute (s) down its concentration gradient.arrow_forward
- The protein gamma globulin has an isoelectric point of 6.60. Suppose you did a pH titration of a solution containing gamma globulin. At what pH will the protein aggregate?arrow_forwardA culture of bacteria growing at 37° C was shifted to 25° C. How would you expect this shift to alter the fatty acid composition of the membrane phospholipids? Explain.arrow_forwardIn the Nernst equation [V = 62 log10 (Co/ Ci)], the term Ci represents: the extracellular concentration of potassium the extracellular concentration of sodium the membrane potential (in millivolts) the intracellular concentration of calcium the intracellular concentration of potassium Which of the following ions must be kept to very low concentrations within the cell cytoplasm in order to allow for enough substrate molecules to synthesize nucleotides and nucleic acids? HCO3- (bicarbonate) Ca2+ (calcium) PO43- (phosphate) Na+ (sodium) K+ (potassium)arrow_forward
- Which of these compounds will cross the cell membrane without the aid of a membrane transport protein, and why? H3 NH NH 2. By what transport process will the above compound be transported? What are the factors which drive movement across the membrane in this process? Does this process require input of energy?arrow_forwardIf you start with 100 mM Na+ and 100 mM K+ outside the liposomes, and 100 mM Na+ and 100 mM K+ inside the liposomes like in (A), then you add ATP to the solution outside the liposomes, then how will the Na+ and K+ concentrations change?arrow_forwardUncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest? A.) 1%, >99%, stomach B.) >99%, 1%, stomach C.) 1%, >99%, blood vessel D.) 50%, 50%, blood vessel E.)>99%, 1%, blood vessel F.) 50%, 50%, stomacharrow_forward
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The Cell Membrane; Author: The Organic Chemistry Tutor;https://www.youtube.com/watch?v=AsffT7XIXbA;License: Standard youtube license