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Biochemistry

6th Edition
Reginald H. Garrett + 1 other
ISBN: 9781305577206

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BuyFindarrow_forward

Biochemistry

6th Edition
Reginald H. Garrett + 1 other
ISBN: 9781305577206
Textbook Problem

Answers to all problems are at the end of this book. Detailed solutions are available in the Student Solutions Manual, Study Guide, and Problems Book.

Understanding Diffusion of Proteins in Membranes Protein lateral motion is much slower than that of lipids because proteins are larger than lipids. Also, some membrane proteins can diffuse freely through the membrane, whereas others art bound or anchored to other protein structures, in the membrane. The diffusion constant for the membrane protein fibronectin is approximately 0.7 X 10-12 cm/sec, whereas that for rhodopsin is about 3 X10-9 cm/sec.

  1. Calculate the distance traversed by each of these proteins in 10 msec.
  2. What could you surmise about the interactions of these proteins with other membrane components?

Interpretation Introduction

(a)

To calculate:

The distance traversed by each of these proteins in 10 msec.

Introduction:

Diffusion is a spontaneous movement of particles from a high concentration area to low concentration area.

Explanation

The distance traversed by fibronectin can be determined from the diffusion coefficient and time given.

  r =  [ 4( 0 .7×10 -12 cm 2 /sec ) ( 10×10 -3 sec )] 1/2 ( 2.8× 10 -14 cm 2 ) 1/2= 1.7× 10 -7cm= 1

Interpretation Introduction

(b)

To determine:

The surmise about the interactions of these proteins with other membrane components should be mentioned.

Introduction:

Membrane proteins are proteins that interact with, or are part of, biological membranes. They include integral membrane proteins that are permanently anchored or part of the membrane and peripheral membrane proteins that are only temporarily attached to the lipid bilayer or to other integral proteins.

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