Olestra is a fat substitute approved by the FDA for use in snack foods. Because there have been anecdotal reports of gastrointestinal problems associated with olestra consumption, a randomized, double-blind, placebo-controlled experiment was carried out to compare olestra potato chips to regular potato chips with respect to GI symptoms (“Gastrointestinal Symptoms Following Consumption of Olestra or Regular Triglyceride Potato Chips,” J. of the Amer. Med. Assoc., 1998: 150–152). Among 529 individuals in the TG control group, 17.6% experienced an adverse GI
a. Carry out a test of hypotheses at the 5% significance level to decide whether the incidence rate of GI problems for those who consume olestra chips according to the experimental regimen differs from the incidence rate for the TG control treatment.
b. If the true percentages for the two treatments were 15% and 20%, respectively, what
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Chapter 9 Solutions
Student Solutions Manual for Devore's Probability and Statistics for Engineering and the Sciences, 9th
- Angioplasty is a medical procedure in which an obstructed blood vessel is widened. In some cases, a wire mesh tube, called a stent, is placed in the vessel to help it remain open. The article “Long-term Outcomes of Patients Receiving Drug-eluting Stents” (A. Philpott, D. Southern, et al., Canadian Medical Association Journal, 2009:167–174) presents the results of a study comparing the effectiveness of a bare metal stent with one that that has been coated with a drug designed to prevent reblocking of the vessel. A total of 5320 patients received bare metal stents, and of these, 841 needed treatment for reblocking within a year. A total of 1120 received drug coated stents, and 134 of them required treatment within a year. a) Find a 98% confidence interval for the differences between the proportions for drug coated stents and bare metal stents. b) Suppose that additional patients are to be treated in order to increase the precision of the confidence interval. Three sampling plans are…arrow_forwardAre low-fat diets or low-carb diets more effective for weight loss? This question was addressed in the article “Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal Women: The A TO Z Weight Loss Study: A Randomized Trial” (C. Gardner, A. Kiazand, et al., Journal of the American Medical Association, 2007:969–977). A sample of 77 subjects went on a low-carbohydrate diet for six months. At the end of that time the sample mean weight loss was 4.7 kg with a sample standard deviation of 7.2 kg. A second sample of 79 subjects went on a low-fat diet. Their sample mean weight loss was 2.6 kg with a standard deviation of 5.9 kg. a) Can you conclude that the mean weight loss is greater for those on the low-carbohydrate diet? b) Can you conclude that the mean weight loss on the low-carbohydrate diet is more than 1 kg greater than that of the low-fat diet?arrow_forwardIn Clinical Trial Q, the sample of patients who had acute myelomonocytic leukemia, per statistical analysis, did not appear to have been affected by the investigational product. However, in reality, the treatment did have an effect. This is known as: Type I Error Type 0 Error Type III Error Type II Errorarrow_forward
- A simple random sample of size n=200 drivers with a valid driver's license is asked if they drive an American-made automobile. Of the 200 drivers surveyed, 106 responded that they drive an American-made automobile. Determine if a majority of those with a valid driver's license drive an American-made automobile at the a=0.05 level of significance. What type of variable is "drive an American-made automobile, or not"? OA. Qualitative with more than two possible outcomes OB. Discrete OC. Continuous OD. Qualitative with two possible outcomesarrow_forwardCalcium and Blood Pressure Does increasing the amount of calcium in our diet reduce blood pressure? Examination of a large sample of people revealed a relationship between calcium intake and blood pressure. Such observational studies do not establish causation. Researchers therefore designed a randomized comparative experiment. The subjects were 21 healthy men who volunteered to take part in the experiment. They were randomly assigned to two groups: 10 of the men received a calcium supplement for 12 weeks, while the control group of 11 men received a placebo pill that looked identical. The experiment was double-blind. The response variable is the decrease in systolic (top number) blood pressure for a subject after 12 weeks, in millimeters of mercury. An increase appears as a negative number. Do the data provide convincing evidence that a calcium supplement reduces blood pressure more than a placebo, on average, for subjects like the ones in this study? Group 1 (calcium) Group (placebo)…arrow_forwardGive the null and alternative hypothesis of The following are the laboratory results in hemoglobin of 10 male (X1) and 10 female(X2) patients. Test the null hypothesis that there is no significant difference between the hemoglobin of male and female patients. Use the t -test at 0.05 level of significance. As part of the National Health Survey conducted by the Department of Health and Human Services, perceptions on the attitude and practices of vaccine were obtained for females aged 18-30 before and after intervention. Listed below are sample mean results. Is there sufficient evidence to support the claim that there is a difference in the attitude and practice between before and after intervention? Use a 0.05 significance level. A researcher determines the BMI index of geriatrics from Tondo. Using 0.05 level of significance, is the BMI index of geriatrics are within the accepted norm (21)?arrow_forward
- Aspirin and Cardiovascular Disease. In the article by P. Ridker et al. titled “A Randomized Trial of Low-dose Aspirin in the Primary Prevention of Cardiovascular Disease inWomen” (New England Journal of Medicine, Vol. 352, pp. 1293–1304), the researchers noted that “We randomly assigned 39,876 initially healthy women 45 years of age or older to receive 100 mg of aspirin or placebo on alternate days and then monitored them for 10 years for a first major cardiovascular event (i.e., nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes).”arrow_forwardUsing an AES analysis of 1000 randomly selected samples of commercial bronze, 10.6% of the metal is Zinc. With a significance level of 0.05, test the hypothesis that the total metal concentration in all commercial bronze is greater than 12.5% Zinc.arrow_forwardUsing an AES analysis of 1000 randomly selected samples of commercial bronze,10.6% of the metal is Zinc. With a significance level of 0.05, test the hypothesis that the total metal concentration in all commercial bronze is greater than12.5% Zinc.arrow_forward
- A new approach to prenatal care is proposed for pregnant women living in a ruralcommunity. The new program involves in-home visits during the course of pregnancy inaddition to the usual or regularly scheduled visits. A pilot randomized trial with 15pregnant women is designed to evaluate whether women who participate in the programdeliver healthier babies than women receiving usual care. The outcome is the APGARscore measured 5 minutes after birth. Recall that APGAR scores range from 0 to 10 withscores of 7 or higher considered normal (healthy), 4-6 low and 0-3 critically low. Thedata are shown below.Usual Care 8 7 6 2 5 8 7 3New Program 9 9 7 8 10 9 6 Is there statistical evidence of a difference in APGAR scores in women receiving the newand enhanced versus usual prenatal care? How you are going to prove this significance?arrow_forwardA case−control study was performed among 145 subjects with macular degeneration and 34 controls, all of whom were 70- to 79-year-old women. A genetic risk score was developed to help differentiate the cases from the controls. The risk score was categorized into six groups (1, 2, 3, 4, 5, 6), with 6 being the highest risk and 1 being the lowest risk.The data in Table 10.48 were obtained relating the risk score to case/control status. taBlE 10.48 risk score cases controls 1 3 11 2 7 3 3 6 6 4 10 8 5 11 2 6 108 4 total 145 34 10.139 What test can be performed to study the asso- ciation between case/control status and risk score? Spe- cifically, we are interested in testing whether cases tend to have consistently higher risk scores or consistently lower risk scores than controls.arrow_forwardA new approach to prenatal care is proposed for pregnant women living in a rural community. The new program involves in-home visits during the course of pregnancy in addition to the usual or regularly scheduled visits. A pilot randomized trial with 15 pregnant women is designed to evaluate whether women who participate in the program deliver healthier babies than women receiving usual care. The outcome is the APGAR score measured 5 minutes after birth. Recall that APGAR scores range from O to 10 with scores of 7 or higher considered normal (healthy), 4-6 low, and 0-3 critically low. Is there statistical evidence of a difference in APGAR scores in women receiving the new and enhanced versus usual prenatal care? The most suitable statistical test to answer this research objective is a. Chi-Square Test b. Mann-Whitney U Test c. Wilcoxon Signed Ranks Test d. Kruskal-Wallis Testarrow_forward
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