The article “The Effects of a Low-Fat, Plant-Based Dietary Intervention on Body Weight, Metabolism, and Insulin Sensitivity in Postmenopausal Women” (Amer. J. of Med., 2005: 991–997) reported on the results of an experiment in which half of the individuals in a group of 64 postmenopausal overweight women were randomly assigned to a particular vegan diet, and the other half received a diet based on National Cholesterol Education Program guidelines. The sample
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Student Solutions Manual for Devore's Probability and Statistics for Engineering and the Sciences, 9th
- In its January 25, 2012, issue, the Journal of the American Medical Association reported on the effects of overconsumption of low, normal, and high protein diets on weight gain, energy expenditure, and body composition. Researchers conducted a single blind, randomized controlled trial of 25 U.S. adults. The subjects were healthy, weight-stable, male and female volunteers, aged 18 to 35 years. All subjects consumed a weight-stabilizing diet for 13 to 25 days. Afterwards, the researchers randomly assigned participants to diets containing various percentages of energy from protein: 5% (low protein), 15% (normal protein), or 25% (high protein). The subjects were not aware of the specific protein level diet to which they were assigned. On these diets the researchers overfed the participants during the last 8 weeks of their 10 to 12 week stay in the inpatient metabolic unit. The goal was to investigate the effect of overconsumption of protein on weight gain, energy expenditure, and body…arrow_forwardAspirin and Cardiovascular Disease. In the article by P. Ridker et al. titled “A Randomized Trial of Low-dose Aspirin in the Primary Prevention of Cardiovascular Disease inWomen” (New England Journal of Medicine, Vol. 352, pp. 1293–1304), the researchers noted that “We randomly assigned 39,876 initially healthy women 45 years of age or older to receive 100 mg of aspirin or placebo on alternate days and then monitored them for 10 years for a first major cardiovascular event (i.e., nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes).”arrow_forwardAngioplasty is a medical procedure in which an obstructed blood vessel is widened. In some cases, a wire mesh tube, called a stent, is placed in the vessel to help it remain open. The article “Long-term Outcomes of Patients Receiving Drug-eluting Stents” (A. Philpott, D. Southern, et al., Canadian Medical Association Journal, 2009:167–174) presents the results of a study comparing the effectiveness of a bare metal stent with one that that has been coated with a drug designed to prevent reblocking of the vessel. A total of 5320 patients received bare metal stents, and of these, 841 needed treatment for reblocking within a year. A total of 1120 received drug coated stents, and 134 of them required treatment within a year. a) Find a 98% confidence interval for the differences between the proportions for drug coated stents and bare metal stents. b) Suppose that additional patients are to be treated in order to increase the precision of the confidence interval. Three sampling plans are…arrow_forward
- Popular Diets. In the article “Comparison of the Atkins, Ornish, Weight Watchers, and Zone Diets for Weight Loss and Heart Disease Risk Reduction” (Journal of the American Medical Association, Vol. 293, No. 1, pp. 43–53), M. Dansinger et al. conducted a randomized trial to assess the effectiveness of four popular diets for weight loss. Overweight adults with average body mass index of 35 and ages 22–72 years participated in the randomized trial for 1 year. The weight losses, in kilograms, based on the results of the experiment are given on the WeissStats site. Negative losses are gains. WW = Weight Watchers. a. Obtain individual normal probability plots and the standard deviations of the samples. b. Perform a residual analysis. c. Use your results from parts (a) and (b) to decide whether conducting a one-way ANOVA test on the data is reasonable. If so, also do parts (d) and (e). d. Use a one-way ANOVA test to decide, at the 5% significance level, whether the data provide sufficient…arrow_forwardVitamin E and the Risk of Prostate Cancer: Klien et al (2011) conducted the following study to determine the effect of vitamin E and selenium treatment on the risk of developing prostate cancer in healthy men. A total of 34,887 men from different study sites in the United States, Canada, and Puerto Rico were randomly selected. To be eligible to participate, the men had to take a rectal examination that showed he was not suspicious of having prostate cancer and be aged 50 years or older for black men and 55 years or older for all others. Each man was randomly assigned to receive one of four treatments: selenium, vitamin E, selenium and vitamin E together, or a placebo. The men were followed up after 8 years to see if they had developed prostate cancer or not. The main question of interest is to determine if the risk of developing prostate cancer differs by the treatment taken. The data are summarized in the table below: No Prostate Cancer Prostate Cancer Total Selenium 8,752 8,737 8,702…arrow_forwardKava is a beverage or extract that is made from Piper methysticum, a plant native to the western Pacific islands. Suppose that, in a randomized comparative experiment to determine if taking kava daily can reduce insomnia, a group of participants with insomnia were randomly assigned to take kava (treatment group) or a placebo (control group). After six weeks, the participants were interviewed to see if they experienced a decrease in insomnia. The table shows the results from the sample. The counts are the number of people in each group who experienced a decrease in insomnia. Group Description Population proportion Sample size Sample count Sample proportion 1 Treatment (kava) P1 n₁ = 402 x1 = 213 P₁ = 0.5299 2 Control (placebo) P2 n₂ = 521 x₂ = 121 P2 = 0.2322 Compute the standard error estimate, SE, of the difference in the sample proportions. Give your answer to at least four decimal places. 0.0438 SE = Incorrect Determine the value of the two-sample z-statistic for the difference in…arrow_forward
- An experiment was conducted for better understanding of the effectiveness of a particular type of drug for reducing bad cholesterol (LDL) level. The purpose of the experiment was to determine whether different dosages used have significant different outcomes in average LDL reduction. Twenty subjects with LDL at around 250 to 300 mg/dL had participated in the study and were randomly divided into four groups. Each group was given a specific level of dosage of the drug each day for one month, with a control group that only provided with placebo. The reduction in LDL was recorded and showed in the following table. Positive number indicates reduction and negative numbers indicates increasing in DLD. Use statistical software to analyze the data and answer the following question. Control Light Dosage Level Medium Dosage Level Heavy Dosage Level 7 25 73 81 -3 17 60 71 6 22 55 79 5 21 41 60 15 12 36 85 Perform a One-way…arrow_forwardBeard et al. (Lancet, 1982:455) described a randomised trial to determine if a low sodium diet was an effective substitute for pharmacological control of hypertension. 90 patients on medication for mild hypertension were allocated at random into two groups. The 45 participants in the intervention group (diet group) were encouraged to adopt a diet free from sodium. The other 45 participants (control group) were asked to continue their usual diet. All the participants were kept under close surveillance to see if it was possible to discontinue the medication for hypertension without detriment. In the diet group, medication was discontinued for 14 participants and in the control group for 4 participants. Draw a 2 by 2 table Carry out a significance test to compare the intervention (diet group) and control group with respect to discontinuation of medication for hypertension Write a brief report on your conclusion.arrow_forwardBeard et al. (Lancet, 1982:455) described a randomised trial to determine if a low sodium diet was an effective substitute for pharmacological control of hypertension. 90 patients on medication for mild hypertension were allocated at random into two groups. The 45 participants in the intervention group (diet group) were encouraged to adopt a diet free from sodium. The other 45 participants (control group) were asked to continue their usual diet. All the participants were kept under close surveillance to see if it was possible to discontinue the medication for hypertension without detriment. In the diet group, medication was discontinued for 14 participants and in the control group for 4 participants.a) Draw a 2 by 2 table .b) Carry out a significance test to compare the intervention (diet group) and control group with respect to discontinuation of medication for hypertension.c) Write a brief report on your conclusion.arrow_forward
- In a study on the effect of an oral rinse on plaque buildup on teeth, sixteen people whose teeth were thoroughly cleaned and polished were randomly assigned to two groups of eight subjects each. Both groups were assigned to use oral rinses (no brushing) for a 2-week period. Group 1 used a rinse that contained an antiplaque agent. Group 2, the control group, received a similar rinse except that the rinse contained no antiplaque agent. A measure of plaque buildup was recorded at 14 days with means and standard deviations for the two groups shown in the table. Control Group Antiplaque Group Sample Size 8 8. Mean 1.22 0.77 Standard Deviation 0.33 0.33 n USE SALT (a) State the null and alternative hypotheses that should be used to test the effectiveness of the antiplaque oral rinse. O Ho: (H, - H2) = 0 versus H: (, - H2) 0 O Ho: (H1 - H2) = 0 versus H,: (H, - H2) > 0 O Ho: (H1 - H2) = 0 versus H.: (4, - H2) # 0 (b) Do the data provide sufficient evidence to indicate that the oral…arrow_forwardResearchers recruited 1000 10- and 20-year-olds to participate in a study about age differences in aggression and the impact of violent video games on aggression. For 1-hour per day, half the participants were randomly assigned to play violent video games, while the other half played a nonviolent video game. A test for aggression was administered at the end of the year, and each participant received a score between 1 and 50 (higher scores indicate greater aggression). The results of the study are shown below: Factor 1 10 years 20 years old old Violent 35 25 Factor games 2 Nonviolent 25 45 games Is there a main effect of age? If so, which age shows more aggression?arrow_forwardSleep apnea is a disorder in which there are pauses in breathing during sleep. People with this condition must wake up frequently to breathe. The article “Postoperative Complications in Patients With Obstructive Sleep Apnea Syndrome Undergoing Hip or Knee Replacement: A Case-Control Study” (R. Gupta, J. Parvizi, et al., Mayo Clinic Proceedings, 2001:897–905) reported that in a sample of 427 people 65 and over, 104 of them had sleep apnea. a) Find a 95% confidence interval for the proportion of those 65 and over who have sleep apnea. b) Find a 99% confidence interval for the proportion of those 65 and over who have sleep apnea. c) Find the sample size needed for a 95% confidence interval to specify the proportion to within ±0.03. d) Find the sample size needed for a 99% confidence interval to specify the proportion to within ±0.03.arrow_forward
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