Genetic Analysis: An Integrated Approach Plus Mastering Genetics with Pearson eText -- Access Card Package (3rd Edition) (What's New in Genetics)
3rd Edition
ISBN: 9780134807799
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter E, Problem 12P
Three independently assorting STR markers (A, B, and C) are used to assess the paternity of a colt recently born to a quarter horse mare. Blood samples are drawn from the mare, her colt, and three possible male sires (
a. Evaluate the data and determine if any of the potential sites can be excluded. Explain the basis of exclusion, if any, in each case.
b. Calculate the PI and CPI based on these STR markers, using the following population frequencies:
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Below is a pedigree showing transmission of a disease; affected individuals are
indicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNA
samples from each individual in the pedigree were spotted in identical fashion on each membrane. Each
individual's DNA appears directly below his or her position in the pedigree. Each membrane was
hybridized with allele specific oligonucleotides that detect the two alternative alleles of a single SNP locus
(ASO 1 and ASO 2). Positive hybridization is represented as a filled circle and lack of hybridization is
represented as an open circle.
I
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III
IV
V
ASO 1
ASO 2
To
1 2 3 4 5 6
a. What is the mode of transmission of this disease?
12
b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene?
c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.
d. Individual V-1 is an unborn fetus. If the SNP locus is 10 CM from the disease locus, what is the
likelihood that he will…
A RFLP is discovered that is linked to the gene for Duchenne’s muscular dystrophy (DMD). DMD is an X-linked, recessive trait. The RFLP is 2 map units from the gene for DMD. Consider the following pedigree and Southern blot using a probe that hybridizes to the RFLP.
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Which band/s is/are associated with DMD?
What is the genotype for individuals 3 and 4? (Remember, this is an X linked disease, so use X’s and Y’s to denote).
Individual 9 married a man who does NOT have muscular dystrophy, and she is pregnant. DMD is an X-linked trait. What is the probability for their child to have DMD?
 An amniocentesis is performed and it is determined that 9’s child in utero has only a 10 kb band that hybridizes to the same probe used above. What can you say about the child now?
Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL.
A. What would be the physical phenotype of these flies?
B. If PCR was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PCR products?
C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker?
D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?
Chapter E Solutions
Genetic Analysis: An Integrated Approach Plus Mastering Genetics with Pearson eText -- Access Card Package (3rd Edition) (What's New in Genetics)
Ch. E - E.1 What is CODIS? Describe the four most...Ch. E - Compare and constast the terms paternity index...Ch. E - What is exclusion principle? How is it used in...Ch. E - What is the statistical principle underlying...Ch. E - Explain the meaning of identity by descent in the...Ch. E - Prob. 6PCh. E - E.7 The results shown are from a DNA test for four...Ch. E - E.8 Figure illustrates the results of an...Ch. E - E.9 Additional STR allele frequency information...Ch. E - Prob. 10P
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- Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL. A. What would be the physical phenotype of these flies? B. If PC was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PC products? C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker? D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?arrow_forwardDoes a molecular marker have to be polymorphic to be useful in physical mapping studies? Does a molecular marker have to be polymorphic to be useful in linkage mapping (i.e., involving family pedigree studies or genetic crosses)? Explain why or why not.arrow_forwardHere is a DNA agarose gel showing PCR products from a mouse genotyping experiment. Genotyping tells us whether each mouse is a wild type mouse (i.e. not genetically modified) or a mutant mouse. Interpret the results for each mouse 1-3.arrow_forward
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