II. The graph on the right shows the Lineweaver-Burk plots derived from 1/V (umoles/min)1 4.5 kinetic data obtained for flu virus +Relenza enzyme activity as a function of substrate concentration in the presence 4 3.5 and absence of two antiviral inhibitor drugs +Tamiflu 2.5 2 No inhibitor 1.5 -15 -10 -5 0 5 10 15 1/S (HM)1 1. Based on the Lineweaver-Burk plots, determine the Km and Vmax for each condition. Do NOT forget the units. Answers can be expressed either as a fraction or in decimals. No inhibitor: Km Vmax Tamiflu: Km Vmax Relenza: Km = Vmax=

Question

Determine Km and Vmax for no inhibitor,Tamiflu, and Relenza.

II. The graph on the right shows the
Lineweaver-Burk plots derived from
1/V (umoles/min)1
4.5
kinetic data obtained for flu virus
+Relenza
enzyme activity as a function of
substrate concentration in the presence
4
3.5
and absence of two antiviral inhibitor
drugs
+Tamiflu
2.5
2
No
inhibitor
1.5
-15
-10
-5
0
5
10
15
1/S (HM)1
1. Based on the Lineweaver-Burk plots, determine the Km and Vmax for each condition. Do NOT forget the
units. Answers can be expressed either as a fraction or in decimals.
No inhibitor: Km
Vmax
Tamiflu: Km
Vmax
Relenza: Km =
Vmax=
Expand
Transcribed Image Text

II. The graph on the right shows the Lineweaver-Burk plots derived from 1/V (umoles/min)1 4.5 kinetic data obtained for flu virus +Relenza enzyme activity as a function of substrate concentration in the presence 4 3.5 and absence of two antiviral inhibitor drugs +Tamiflu 2.5 2 No inhibitor 1.5 -15 -10 -5 0 5 10 15 1/S (HM)1 1. Based on the Lineweaver-Burk plots, determine the Km and Vmax for each condition. Do NOT forget the units. Answers can be expressed either as a fraction or in decimals. No inhibitor: Km Vmax Tamiflu: Km Vmax Relenza: Km = Vmax=

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