The protein that ensures the fidelity of DNA replication is the a. tumor repressor P53 protein. b. Mitotic arrest deficient protein. c. transcription factor E2F protein. d. Ataxia telangiectasia mutated protein.

Q: Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic…

A: Answer: Introduction: Mutation- These are the random heritable changes that occurs in the DNA…

Q: The BRCA genes produce DNA repair proteins. Genetic testing is available that can determine if a…

A: BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are proteins that aid in the repair of…

Q: Proto-oncogene product causes:   A. stimulation of cell cycle.   B. inhibits cell cycle.   C.…

A: Answer--

Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…

A: The repeated and uncontrollable division of cells forms a large mass called the tumor. Tumors might…

Q: The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene…

A: An oncogene is a type of gene that is responsible for causing the cells to divide uncontrollably and…

Q: Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components…

A: There are two types of cell division.They are Mitosis and Meiosis. Most of the times,the type of…

Q: Virtually all steps of embryological development depend on: a. Alterations in the genome b. Tumor…

A: Embryological development is the growth and development of embryo by  cell division and cell…

Q: 47. hTERT is repressed in these cells: A. Germ cells B. Tumor cells C. Somatic cells D. A and B

A: hTERT is represses in the cells.

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: You found a protein called X in colon cancer patients that is over-expressed and is associated with…

A: Metastasis is the process by which cancer cells spread from the primary tumor site to other parts of…

Q: Characterize the differences between tumor cells and normal cells in terms of the following…

A: A. The normal cell shows contact inhibition that means when two cells get contact then the growth…

Q: Tumor Suppressor Genes are often called as gatekeepers because: a. They signify their involvement…

A: The correct option is a i.e.They signify their involvement in governing the dynamics of cell…

Q: Which of the following is NOT an example of a fail-safe mechanism that prevents the irregular cell…

A: Uncontrolled cell division results in the development of a tumor or cancer. There are many factors…

Q: Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2

A: A normal cell undergoes regulated division, differentiation, and apoptosis (programmed cell death).…

Q: illustrate some of the molecular mechanisms leading from loss-of-function mutations in…

A: Tumor suppressing genes also known as Anti - oncogenes are the  regulatory genes which regulates…

Q: Discuss the interplay between genetics and environment in the development of cancer (it would be…

A: Research on several diseases have found that the cause of diseases are not only environmental or…

Q: Why would the failure of the p53 tumor supressor gene be more likely to cause cancer in a seventy…

A: Tumor protein p53, which plays a crucial role in the cellular response to DNA damage, is one of the…

Q: Match the gene on the left with the gene category on the right.…

A: Genes  Genes are the information coded in a DNA. They make our protein and enzyme. They are…

Q: Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Most inherited forms of cancer involve _______________ and these individuals are for the mutation.…

A: Firstly we can examine what each of the terms given represents. 1. Tumor suppressor gene: It is a…

Q: Much remains unknown about the rapid, uncontrolled growth, or what causes a tumor to metastasize.…

A: Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. A…

Q: In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: The p53 gene is a tumor-suppressor gene while Ras is a proto-oncogene. Mutation in either one can…

A: Tumor suppressor genes are the genes that are involved in various checkpoints in the cell cycle,…

Q: 1. The diagrams (A and B) below represent the two common types of cancer genes; one diagram…

A: Genetic material is nothing but the sequence of nucleic acids which is called as DNA. It contains…

Q: The "initiation" stage of cancer refers to:     a)  The stage where DNA is mutated, and permanent…

A: Introduction :  Cancer is defined by the following characteristics: • Uncontrolled…

Q: Why would a mutation in BRCA1 be considered a driver mutation?  b. Based on what you’ve learned…

A: In this question, we  have to answer 'BRCA gene consider as driver mutation and ATM consider as a…

Q: mutations in breast cancer susceptibility genes BRCA1 & 2 principally cause with ? (a) nucleotide…

A: BRCA1 gene mutations lead to breast cancer in women of around 60% to 80%. Along with that it also…

Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…

A: An oncogene helps in control cell division and  contributes to cancer progression whereas a tumor…

Q: Part A. Gene Q's normal function is to cause apoptosis (cell death) for cells that have chromosome…

A: Cancer in simple term can be referred to a set of diseases which are caused by the production of an…

Q: A tumor suppressor gene (TSG) codes for a protein that is part of the system that regulates cell…

A: Normal genes that halt cell division or fix DNA errors are known as tumor suppressor genes. Such…

Q: Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic…

A: A mutation is a form of alteration in which a single change changes a nucleotide of nucleic acid. It…

Q: Which of the following effectively describes the situation of someone with an inherited…

A: Breast cancer is a condition in which abnormal cells in the breast grow uncontrolled, resulting in a…

Q: Why are PARP inhibitors effective in killing tumor cells with BRCA-deficiency but not Rb deficiency?…

A: Anti-oncogene or tumor suppressor gene regulate cell division and DNA repair mechanism. Any mutation…

Q: A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB,…

A: Introduction :- Mutations are defined as the changes in the DNA sequence and thus , hereditary in…

Q: Tumor-suppressor genes promote cancer whena. they are overexpressed.b. they are expressed in the…

A: Cancer is a disorder in which abnormal cells divide irrepressibly and destroy the tissues of the…

Q: Sometimes, malignant cells do not stay properly anchored in tissues because of the loss of function…

A: Malignancy It refers to the presence of cancerous cells that have the ability to spread to other…

Q: Which could lead to uncontrolled growth in cancer?   A. A nonfunctional E2F protein     B. The…

A: a)A nonfunctional E2F protein: False E2F is a transcription factor that is the principal target of…

Q: P53 is a tumor suppressor protein.   The protein is present in the cell at all times but is…

A: Given information: P53 is a tumor suppressor protein.   The protein is present in the cell at all…

Q: In a recent study, scientists used gene editing to treat both sickle cell disease and…

A: Sickle cell disease and beta thalassemia are genetic disorders caused by errors in genes of…

Q: A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle…

A: Overexpression of RTK (Receptor Tyrosine Kinase) leads to the increased local concentration of the…

Q: RCA1 is a tumor suppressor gene. BRCA1* is the symbol for the non-mutant or wild-type form of the…

A: BRCA1 mutations are also linked to a higher risk of triple-negative breast cancer, which is a very…

Q: Which of the following is an enabling characteristic for cancer that can increase the likelihood of…

A: The somatic mutations in the genome of a cancer cell, irrespective of their structural nature, can…

Q: Which of the following is true of transcription factors? A)The same transcription factors are found…

A: Transcription factors are defined as the protein responsible for controlling the transcription rate…

Q: Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase protein, called…

A: From the above information, we can make the following inferences - 1. p53, as indicated in the…

Q: The diagram shows the relative activity of a proto-oncogene and a tumor supressor gene in a normal…

A: Proto oncogene: The gene that is important for normal cell growth. Mutations in these proto…

Q: Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work.…

A: Cancer is a disease that is associated with genetic changes. The mutations in the oncogenes and…

Q: Imagine you have used cBioportal and breast cancer patient datasets and identified a…

A: Introduction :- Cancer is defined as the uncontrolled and un-regulated proliferation of cells , due…

Q: what are the rolls that the p53 gene and RAS protein take on when trying to stop a cancer cell from…

A: Given: Role of p53 and RAS protein to stop a cancer cell from replication. What happens if mutation…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.