X31b is an experimental compound that is taken up by rapidly dividing cells. Research has shown that X31b stimulates the methylation of DNA. Some cancer researchers are interested in testing X31b as a possible drug for treating prostate cancer. Offer a possible explanation for why X31b might be an effective anticancer drug.

Q: Describe the role of mismatch repair (MMR) in DNA repair.Why do mutations in MMR proteins increase…

A: DNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion, and…

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: Can you please help me by drawing a serie of schematic figures that demonstrates the information in…

A: Proteins undergo post-translational modifications to increase their functional diversity. The…

Q: The BRCA genes produce DNA repair proteins. Genetic testing is available that can determine if a…

A: BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are proteins that aid in the repair of…

Q: With diagrams explain, chromosome rearrangement

A: Chromosomal rearrangement in genetics is the mutation in which the type of mutation causes…

Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…

A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…

Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…

A: The repeated and uncontrollable division of cells forms a large mass called the tumor. Tumors might…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Genetic transformation happens when the genetic composition of an organism is transformed by the…

Q: Could a gene be involved in the growth of both stem cells and some kinds of cancer? Explain your…

A: in stem cells we have an important class of genes called proto-oncogenes [PO] with are necessary for…

Q: Characterize the differences between tumor cells and normal cells in terms of the following…

A: A. The normal cell shows contact inhibition that means when two cells get contact then the growth…

Q: A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins…

A: There are some Mut enzymes that check the identity of newly formed DNA and if there are certain…

Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…

A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…

Q: One important biological effect of a large dose of ionizing radiation is to halt cell division. What…

A: Cell division is the cycle by which a parent cell separates into at least two girl cells. Cell…

Q: What is the difference between an oncogene and a tumor-suppressorgene? Give two examples of each…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: Describe the role of mismatch repair (MMR) in DNA repair. Why can mutations in MMR increase the risk…

A: Mismatch repair of DNA is a repair system that removes and repairs erroneous insertions,…

Q: many cancers have mutations in more than one of these genes how could this happen. how did a single…

A: Cancer or tumor results when there is a normal cell division and there is no control on the cell…

Q: A research study indicated that an agent in cigarette smoke caused the silencing of a tumor…

A: The TP53 gene provides instructions for making a protein called tumor protein p53 (p53). This…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Remember that DNA viruses inactivate tumor suppressor genes resulting in cancer. In Burkitt’s…

A: Translocation of c-myc occurs to one of the immunoglobulin foci. This leads to over expression of…

Q: Which of the following is an example of a proto-oncogene? 1) cell cycle inhibitor 2) tumor…

A: Oncogene The gene that are cancerous and divide cell abnormally.

Q: chromodomains? a) b

A: Answer Chromodomain bind methylated histone tail and are associated with repression.

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: How would you identify patients whose tumor cells are particularly likely to have a somatic mutation…

A: Somatic mutation takes place in all types of cells in the body except the germ cells. Therefore…

Q: What are Ras protein and p53? How can mutations in the genes for these proteins contribute to…

A: TP53 is the gene that translates the protein called tumor protein p53 which acts as a tumor…

Q: Explain why many oncogenic viruses contain genes whose products interact with tumor-suppressor…

A: Viruses are infectious agents. They can only replicate inside the living cells. Viruses can infect…

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Q: mutations in breast cancer susceptibility genes BRCA1 & 2 principally cause with ? (a) nucleotide…

A: BRCA1 gene mutations lead to breast cancer in women of around 60% to 80%. Along with that it also…

Q: Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene…

A: An oncogene helps in control cell division and  contributes to cancer progression whereas a tumor…

Q: Why don’t all loss-of-function mutations that are recessive at the cellular level behave as…

A: Loss of function mutation is otherwise known as inactivating mutations. This type of mutation is…

Q: Because the degree of DNA methylation appears to be a relatively reliable genetic marker for some…

A: Methylation of DNA is a heritable, enzyme-induced modification to DNA structure without alteration…

Q: Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic…

A: A mutation is a form of alteration in which a single change changes a nucleotide of nucleic acid. It…

Q: Several research studies are under way that involve the use of genetherapies to inhibit the growth…

A: Rribonucleic acid (RNA) is genetic material which is made up of nucleotides, which consist of a…

Q: There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes,…

A: It is an uncontrollable cell division that get metastasized into surrounding tissues.

Q: What role do aurora kinase play in the cell cycle and how would using these kinases as target  for…

A: A particular series of events undertaken in proper time frame inside different types of cells when…

Q: Describe the molecular mechanisms involved in P53’s role as a tumor repressor protein

A:

Q: X-inactivation can result in two clones of a cell that differ in the genes they express. Can you…

A: The term genetics refers to the total amount of DNA content present in the cells of an orgaism.…

Q: Do mutations that cause cancer in an individual pass down to his/her offspring? What is the role of…

A: Cancer is the umbrella term for a group of diseases. Any of the body's cells begin to divide without…

Q: A research study indicated that an agent in cigarette smoke caused the silencing of the p53 gene,…

A: In an organism, almost all the changes that occur in gene expression that are epigenetic in nature…

Q: Is PI3K a proto-oncogene or a tumor suppressor gene? Why

A: PI3K means Phospho inositol 3 kinase gene.It is involved in signalling pathways.It is the mutation…

Q: Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a…

A: Proto- oncogene Activation of a proto- oncogene into an oncogene usually includes gain of function…

Q: Name two ways in which loss of p53 function contributes to a malignant phenotype. Explain how…

A: We know that, an abnormal growth of tissues in the body is know as tumor. A tumor can change into…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: induced pluripotent stem cells are the type of stem cells that are produced from the somatic cells…

Q: Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work.…

A: Cancer is a disease that is associated with genetic changes. The mutations in the oncogenes and…

Q: Mutations in the ras gene family induce normal cells to proceed into the replication cycle. This…

A: Proto-oncogene  normal function is to promote cell survival and cell division. Gain of function of…

Cancer Therapy