Concept explainers
Dexamethasone and IQ. In the paper “Outcomes at School Age After Postnatal Dexamethasone Therapy for Lung Disease of Prematurity” (New England Journal of Medicine, Vol. 350, No. 13, pp. 1304–1313), T. Yeh et al. studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy for the prevention of chronic lung disease of prematurity. All of the infants in the study had had severe respiratory distress syndrome requiring mechanical ventilation shortly after birth. On the WeissStats site, we provide the school-age IQs of the 74 children in the control group, based on the study results. Use the technology of your choice to do the following.
- a. Obtain a normal probability plot, boxplot, histogram, and stem-and-leaf diagram of the data.
- b. Based on your results from part (a), can you reasonably apply one-standard-deviation χ2-procedures to the data? Explain your reasoning.
- c. Overall, IQs of school-age children have a standard deviation of 16. At the 1% significance level, do the data provide sufficient evidence to conclude that IQs of school-age children in similar postnatal circumstances as those in the control group of this study have a smaller standard deviation than that of school-age children in general?
- d. Find and interpret a 99% confidence interval for the standard deviation of IQs of all school-age children in similar postnatal circumstances as those in the control group of this study.
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Introductory Statistics (10th Edition)
- The article “Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication. A Randomized Controlled Trial” (M. McDermott, P. Ades, et al., Journal of the American Medical Association, 2009:165–174) reported the results of a study to determine whether treadmill exercise could improve the walking ability of patients suffering from claudication, which is pain caused by insufficient blood flow to the muscles of the legs. A sample of 48 patients walked on a treadmill for six minutes every day. After six months, the mean distance walked in six minutes was 348 meters, with a standard deviation of 80 m. For a control group of 46 patients who did not walk on a treadmill, the mean distance was 309 m with a standard deviation of 89 m. Can you conclude that the mean distance walked for patients using a treadmill is greater than the mean for the controls? Use the α = 0.05 level of significance.arrow_forwardLeisure Activities and Dementia. An article appearing in the Los Angeles Times discussed the study “Leisure Activities and the Risk of Dementia in the Elderly” (New England Journal of Medicine, Vol. 348) by J.Verghese et al. The article in the Times, titled “Crosswords Reduce Risk of Dementia,” contained the following statement: “Elderly people who frequently read, do crossword puzzles, practice a musical instrument or play board games cut their risk of Alzheimer’s and other forms of dementia by nearly two-thirds compared with people who seldom do such activities.” Comment on thestatement in quotes, keeping in mind the type of study for which causation can be reasonably inferred.arrow_forwardIn a study conducted in the Science Department of Faculty of Science, Technology and Human Development in a University; the researcher examined the influence of the drug succinylcholine on the circulation levels of androgens in the blood. Blood samples from wild, free-ranging deer were obtained via the jugular vein immediately after an intramuscular injection of succinylcholine using darts and a capture gun. Deer were bled again approximately 30 minutes after the injection and then released. The level of androgens at time of capture and 30 minutes later, measured in nanograms per milliliter (ng/ml), for 15 deers as in Table Q1. Assuming that the populations of androgen at time of injection and 30 minutes later are normally distributed:i) Find the average and standard deviation of this studyii)Determine the critical region of this problem.iii) Test at the 0.05 level of significance whether the androgen concentrations are altered after 30 minutes of restraint.arrow_forward
- Aspirin and Cardiovascular Disease. In the article by P. Ridker et al. titled “A Randomized Trial of Low-dose Aspirin in the Primary Prevention of Cardiovascular Disease inWomen” (New England Journal of Medicine, Vol. 352, pp. 1293–1304), the researchers noted that “We randomly assigned 39,876 initially healthy women 45 years of age or older to receive 100 mg of aspirin or placebo on alternate days and then monitored them for 10 years for a first major cardiovascular event (i.e., nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes).”arrow_forwardHigh levels of blood sugar are associated with an increased risk of type 2 diabetes. A levelhigher than normal is referred to as “impaired fasting glucose.” The article “Association ofLow-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes andInsulin Resistance in the Strong Heart Family Study” (M. Grau-Perez, C. Kuo, et al.,Environmental Health Perspectives, 2017, online) reports a study in which 47 of 155 peoplewith impaired fasting glucose had type 2 diabetes. Consider this to be a simple randomsample. a) Find a 95% confidence interval for the proportion of people with impaired fasting glucose who have type 2 diabetes. b) Find a 99% confidence interval for the proportion of people with impaired fasting glucose who have type 2 diabetes. c) A doctor claims that less than 35% of people with impaired fasting glucose have type 2 diabetes. With what level of confidence can this claim be made?arrow_forwardLandolt et al. (A-26) examined rates of posttraumatic stress disorder (PTSD) in mothers and fathers. Parents were interviewed 5 to 6 weeks after an accident or a new diagnosis of cancer or diabetes mellitus type I for their child. Twenty-eight of the 175 fathers interviewed and 43 of the 180 mothers interviewed met the criteria for current PTSD. Is there sufficient evidence for us to conclude that fathers are less likely to develop PTSD than mothers when a child is traumatized by an accident, cancer diagnosis, or diabetes diagnosis? Let alpha = 0.05arrow_forward
- Is Seat Belt Use Independent of Cigarette Smoking?A study of seat belt users and nonusers yielded the randomly selected sample data summarized in the given table (based on data from “What Kinds of People Do Not Use Seat Belts?” by Helsing and Comstock,American Journal of Public Health,Vol. 67, No. 11). Test the claim that the amount of smoking is independent of seat belt use. A plausible theory is that people who smoke more are less concerned about their health and safety and are therefore less inclined to wear seat belts. Is this theory supported by the sample data?arrow_forwardA study of “adverse symptoms” in users of over-the-counter pain relief medications assigned subjects at random toone of two common pain relievers: acetaminophen and ibuprofen. In all, 650 subjects took acetaminophen, and 44experienced some adverse symptom. Of the 347 subjects who took ibuprofen, 49 had an adverse symptom. Is thisconvincing evidence that the two pain relievers differ in the proportion of people who experience an adverse symptom?arrow_forwardIn randomized, double-blind clinical trials of a new vaccine, children were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 116 of 651 subjects in the experimental group (group 1) experienced fever as a side effect. After the second dose, 73 of 532 of the subjects in the control group (group 2) experienced fever as a side effect. Does the evidence suggest that a higher proportion of subjects in group 1 experienced fever as a side effect than subjects in group 2 at the α=0.10 level of significance? #1 Find the test statistic for this hypothesis test.arrow_forward
- NCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forwardNCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forwardNCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forward
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