BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
9th Edition
ISBN: 9781319425784
Author: BERG
Publisher: Macmillan Higher Education
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Chapter 12, Problem 15P
Interpretation Introduction
Interpretation:
The number of potentials of interactions of v- SNARE and t- SNARE interactions needs to be determined.
Concept introduction:
A SNARE protein on the vesicle which is called v- SNARE and a SNARE protein on the target membrane which is otherwise known as the t-Snare are mandatory for the intracellular vesicle fusion.
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proteins. Which of the following will tell you whether a protein would be found in the lumen of the ER?
A. You run a hydropathy plot an look for hydrophobic peaks that span 20-30 amino acids
B. You isolate microsomes and see whether the proteins are inserted into the membrane of the microsome
C. You run a hydropathy plot an look for a lack of hydrophobic peaks that span 20-30 amino acids
O D. You do in vitro translation of each protein in the presence or absence of microsomes and look to see whether there is a size change in the presence
of microsomes.
BONUS QUESTION! In neurons, the proteolytic enzyme y-secretase produces the Aß amyloid peptides shown below. The AB40 peptide is thought to play a protective role in the neuron. However, the AB42 peptide appears
to be toxic since it is found in the amyloid plaques that cause Alzheimer's Disease (AD). AB40 and AB42 are identical, except that AB42 contains two extra amino acid residues (shown in red) at the C-terminal end. Based on
your knowledge of amino acids and proteins, which of the following factors is most likely to explain the greater plaque-forming activity of AB42 compared to AB40?
Sequence of Aß40: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence of AB42: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
O The greater length of AB42 makes it more likely to aggregate and form plaques.
O AB42 has a lower pl than AB40, which makes it more likely to aggregate at physiological pH.
O AB42 is more hydrophobic than AB40, which makes it harder to clear from the cell and thus more likely to…
Please help me with this question. More than one answer may be correct. THe graph relating to the information is included below.
The figure shows the number of cells that have clusters of IRE1 molecules after those cells are treated with various levels of thapsigargin (Tg), a chemical that can induce ER stress. IRE1 can form these clusters when ER stress is induced and this clustering can cause activation of RNAse activity in IRE1. In this experiment, normal IRE1 was used (IRE1α) that can bind to Sec61, along with a modified version of IRE1 that binds to Sec61 more weakly than normal IRE1 (wIRE1α), and another modified version that binds to Sec61 more strongly than normal IRE1 (sIRE1α). From this figure you can conclude that:
Question 18 options:
IRE1 binding to Sec61 promotes the formation of IRE1 clumps
IRE1 binding to Sec61 prevents the formation of IRE1 clumps
co-translational translocation is a key process
the golgi aparatus is heavily involved in the unfolded protein response
The…
Chapter 12 Solutions
BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
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