ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 12, Problem 18P
The first page of this chapter displays photos of Rainbow and her clone, CC. Both cats are tabby (their colored fur has a mottled pattern) and both have white regions, mainly on their bellies and legs. However, a major difference exists in their appearances. Rainbow is a calico tabby; she has black and orange spots controlled by alleles of the X-linked O gene, where the dominant trait is black (O-) and the recessive trait is orange (oo). However, Rainbow’s clone, CC, is a black tabby; she lacks the orange spots.
CC was made by transferring into an enucleated oocyte a single nucleus from one of Rainbow’s diploid somatic cells. That diploid oocyte, a mimic of a fertilized egg, was then implanted in the uterus of a surrogate mother. (The process of cloning by somatic cell nuclear transfer will be described in more detail in Chapter 18.)
| a. | What is Rainbow’s (and CC’s) genotype for the O gene?? |
| b. | Given that CC was made from a single one of Rainbow’s somatic cell nuclei, explain the difference between CC’s and Rainbow’s appearances. |
| c. | Would every clone of Rainbow’s c. be a black tabby like CC, or do other possibilities exist? Explain. |
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The first page of this chapter displays photos ofRainbow and her clone, CC. Both cats are tabby (theircolored fur has a mottled pattern) and both have whiteregions, mainly on their bellies and legs. However, amajor difference exists in their appearances. Rainbowis a calico tabby; she has black and orange spots controlled by alleles of the X-linked O gene, where thedominant trait is black (O-) and the recessive trait isorange (oo). However, Rainbow’s clone, CC, is ablack tabby; she lacks the orange spots. CC was made by transferring into an enucleatedoocyte a single nucleus from one of Rainbow’s diploid somatic cells. That diploid oocyte, a mimic of afertilized egg, was then implanted in the uterus of asurrogate mother. (The process of cloning by somaticcell nuclear transfer will be described in more detailin Chapter 18.)a. What is Rainbow’s (and CC’s) genotype for theO gene?b. Given that CC was made from a single one ofRainbow’s somatic cell nuclei, explain the difference between CC’s…
Let’s suppose that two different X-linked genes exist in mice,designated with the letters N and L. Gene N exists in a dominant,normal allele and in a recessive allele, n, that is lethal. Similarly,gene L exists in a dominant, normal allele and in a recessive allele,l, that is lethal. Heterozygous females are normal, but males thatcarry either recessive allele are born dead. Explain whether or notit would be possible to map the distance between these two genesby making crosses and analyzing the number of living and deadoffspring. You may assume that you have strains of mice in whichfemales are heterozygous for one or both genes.
X-linked ichthyosis is an X-linked recessive trait that manifests in part as dry, scaly skin (“ichthy-” = fish or fish like). Suppose a couple are considering having a child together. Parent A is heterozygous for the ichthyosis allele while Parent B is hemizygous negative for the ichthyosis allele. What is the probability their child would be unafflicted with ichthyosis but be a carrier of the ichthyosis-causing allele?
a.0%
b.25%
c.50%
d.75%
e.100%
Chapter 12 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Normal vision (XA) in humans is dominant to color blindness (Xa) and is X-linked. A man with normal vision, whose father was colorblind, marries a colorblind woman. What are the chances that a son will be colorblind? What are the chances that a daughter will be colorblind? The determiner for brown eyes (B) is dominant to blue eyes (b) and is not X-linked. A colorblind man with brown eyes, whose mother was blue-eyed, marries a blue-eyed woman having normal vision, whose father was colorblind. Show the expected phenotypes ratio of their children involving eye color, color blindness, and sex.arrow_forwardHemophilia is another example of a X-linked disease caused when a recessive allele (Xh) is expressed. If a normal male reproduces with a heterozygous normal female, what are the expected genotypes and phenotypes? Will any of their daughters develop hemophilia? As in the previous question, you must also give the gender of the child in your genotype and phenotype descriptions here.arrow_forwardIn humans, the genes for red-green color blindness (R = normal, r = color blind) and hemophilia A (H = normal, h = hemophilia) are both X-linked and only 3 map units apart. Suppose a woman has four sons, and two are color blind but have normal blood clotting and two have hemophilia but normal color vision. What is the probable genotype of the woman? HR/hr Hr/hr hr/hR Hr/hR HR/Hrarrow_forward
- Anhidrotic ectodermal dysplasia is an X-linked recessive disorder in humans characterized by small teeth, no sweat glands, and sparse body hair. This trait is usually seen in men, but women who are heterozygous carriers of the trait often have irregular patches of skin with few or no sweat glands (see the illustration below). Q. Explain why women who are heterozygous carriers of a recessive gene for anhidrotic ectodermal dysplasia have irregular patches of skin lacking sweat glands.arrow_forwardIn humans, red-green color-blindness is a recessive X-linked trait. A man with red-green color- blindness marries a normal-vision woman whose father was color-blind. As the genetic counselor, construct a Punnett square to determine the genotypic and phenotypic possibilities of their children. orange is due to heteroz means In human, assume that albinism is an autosomal recessive characteristic while hemophilia is X-linked recessive. An albino nonhemophiliac man has children with a normally-pigmented nonhemophiliac woman whose father was a hemophiliac and whose mother was albino. Calculate the phenotypes of the children they could produce.arrow_forwardHemophilia is another example of a X-linked disease caused when a recessive allele (Xh) is expressed. If a normal male reproduces with a heterozygous normal female, what are the expected genotypes and phenotypes? Will any of their daughters develop hemophilia? you must also give the gender of the child in your genotype and phenotype descriptions here.arrow_forward
- Anhidrotic ectodermal dysplasia is an X-linked recessive disorder in humans characterized by small teeth, no sweat glands, and sparse body hair. This trait is usually seen in men, but women who are heterozygous carriers of the trait often have irregular patches of skin with few or no sweat glands (see the illustration below). a. Explain why women who are heterozygous carriers of a recessive gene for anhidrotic ectodermal dysplasia have irregular patches of skin lacking sweat glands. b. Why does the distribution of the patches of skin lacking sweat glands differ among the females depicted in the illustration, even between the identical twins?arrow_forwardA male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: Oa. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% LENA C Transcribed Image Text: A male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: O a. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% Po 11 W *****arrow_forwardConsider a couple: a woman who is homozygous for a recessive mutation that causes X-linked colorblindness, and a man with full color vision (he does not carry a copy of the mutation). a) What is the probability that a son of this couple will be colorblind? b) What is the probability that a daughter of the couple will be colorblind?arrow_forward
- Congenital hypertrichosis (CH) is a very rare X-linked dominant inherited condition. CH is characterized by the growth of dark hair over the body. CH is so rare, only 50 cases have been identified since the Middle Ages. The incidence of this condition is considerably higher in a small Mexican village (from which the partial pedigree below is derived) than the rest of the human population. I II III Use the following information to answer the two questions. IV D II-4 8 9 IV-6 0=10~ 11 1. Using appropriate nomenclature, identify the genotypes for the following 2 individuals: 12 13 your response must include an appropriate legend/key to identify allele symbols. 2. Show how a Punnett square (using the allele symbols from the previous question) is used to determine the probability in percent of individuals III-11 and III-12 next offspring has CH?arrow_forwardThe gene causing Coffin-Lowry syndrome (OMIM 303600) was recently identified and mapped on the human X chromosome. Coffin-Lowry syndrome is a rare disorder affecting brain morphology and development. It also produces skeletal and growth abnormalities, as well as abnormalities of motor control. Coffin-Lowry syndrome affects males who inherit a mutation of the X-linked gene. Most carrier females show no symptoms of the disease but a few carriers do. These carrier females are always less severely affected than males. Offer an explanation for this finding.arrow_forwardMales of many diploid species (like us) have X and Y sex chromosomes. They are hemizygous for most X- linked genes. Thus, males express most X-linked alleles, whether they are dominant or recessive in females. In the fruit fly Drosophila, it is common to achieve the equivalent of a test cross of X-linked genes in females by assessing the readily observed phenotypes of their male progeny. Since males do not receive X-linked genes from their father, sires of these crosses can be normal or wild-type flies. In fly genetics, it is conventional to name a gene after the mutant phenotype that enabled its discovery. Your challenge is to establish gene order and map distances between three X-linked genes in Drosophila. Each gene is represented by recessive mutant alleles that express rather distinctive phenotypes relative to their dominant wild-type alternative alleles. Flies expressing fruitless (f) are bisexual, lush (1) have a heightened responses to ethanol, and ken&barbie (kb) lack external…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY