a. To determine: The explanation for the results obtained. Introduction: The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Question

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Answer 1

Question

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

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. a. Mice engineered to block expression of the geneencoding the telomerase protein age at a muchfaster rate than normal and have decreased lifespans. When expression of the telomerase proteinis turned back on in mice that are prematurely old,many negative effects of this aging are rapidly anddramatically reversed. Provide a possible explanation for these results.b. The results of these mouse experiments have ledsome researchers to propose that treatments thatcould lead to overexpression of the telomerase genemight serve as a “fountain of youth” leading to reversal of aging in humans. Why do you think weshould be very cautious about trying such treatments? Your argument should address why it mightbe advantageous to multicellular organisms for mostof their somatic cells not to express telomerase.

Telomerase is an attractive cancer target since 85% - 90% of tumors express telomerase (while normal cells express little to no telomerase). One paradigm in this model is the “cancer stem cell” hypothesis. Cancer stem cells (or tumor-initiating cells with stem-cell like properties) can self-renew, as well as give rise to heterogeneous tumor cell populations (essentially, they are believed to be responsible for the formation and maintenance of the tumor). If these cells are indeed “stem-like” they also divide more slowly, and presumably express telomerase (like normal stem cells).Do you think a treatment strategy that inhibits telomerase would be effective in treating cancer? How does the cancer stem cell hypothesis complicate or compliment these strategies? Justify your answer.

a. How many enhancers were you able to identify with these set of experiments? Explain. b. If you find any enhancer, in what genetic region, number of base pairs upstream from MRPA, are they located? Explain.

Answer 2

Question

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Expert Solution & Answer

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Answer 3

Question

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Expert Solution & Answer

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Answer 4

Question

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Expert Solution & Answer

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Answer 5

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Answer 6

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Answer 7

Chapter 12, Problem 23P

Summary Introduction

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Answer 8

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Answer 9

Summary Introduction

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...

a. To determine: The explanation for the results obtained. Introduction: The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Solution Summary: The author explains telomerase, a ribonucleoprotein, is involved in the inhibition of chromosome shortening.

Concept explainers

Videos

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Want to see the full answer?

Chapter 12 Solutions

a. To determine: The explanation for the results obtained. Introduction: The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

Solution Summary: The author explains telomerase, a ribonucleoprotein, is involved in the inhibition of chromosome shortening.

Concept explainers

Videos

a. To determine: The explanation for the results obtained. Introduction: The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

b. To determine: The reason one should be cautious while trying treatments. Introduction: The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.

Want to see the full answer?

Chapter 12 Solutions

a.

To determine:

The explanation for the results obtained.

Introduction:

The telomerase refers to a ribonucleoprotein that adds a repeat sequence to the 3' end of the telomeres.

b.

To determine:

The reason one should be cautious while trying treatments.

Introduction:

The enzyme telomerase is responsible for maintaining the length of the telomeres. The telomerase enzymes add a repetitive guanine-rich sequence to the telomeres.