ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
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Chapter 12, Problem 8P
About 2000 G bands are visible in a high-resolution karyotype of the 3 billion base pairs in the haploid human genome. If the genome contains about 27,000 genes, about how many genes would be removed by a deletion of DNA that could be detected by karyotype analysis?
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Using a laser beam, you isolated several R bands from human chromosomes. Answer the following questions
What kinds of genes are present in R bands?
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A diploid (ie, contains TWO sets of chromosomes) organisms with a 45,000-kb haploid (counts only one set of its chromosomes) genome contains 21% G residues. Calculate the number of A, C, G< and T residues in the DNA of each cell in this organism.
Can you help explain why this is the answer, thank you!
Answer: Since the haploid genome contains 21% G, it must contain 21% C (Because G=C) and 58% A + T, or 29% A and 29% T. Each cell is a diploid, containing 90,000 kb or 9x10^7 bases. Therefore, A=T = (0.29)(9x10^7) = 2.61 x 10^7 bases and G=C=(0.21)(9x10^7) = 1.89x10^7 bases.
Human adult hemoglobin is a tetramer containing two alpha (a) and two beta (b) polypeptide chains. The a gene cluster on chromosome 16 and the b gene cluster on chromosome 11 share amino acid similarities such that 61 of the amino acids of the a@globin polypeptide (141 amino acids long) are shared in identical sequence with the b@globin polypeptide (146 amino acids long). How might one explain the existence of two polypeptides with partially shared function and structure on two different chromosomes?
Chapter 12 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
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