GENETICS(LL)-W/CONNECT >CUSTOM<
6th Edition
ISBN: 9781260571561
Author: HARTWELL
Publisher: MCG CUSTOM
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Textbook Question
Chapter 12, Problem 34P
a. | Give at least three examples of types of mutations that would disrupt the process of mitotic chromosome segregation. That is, explain in what DNA structures or in genes encoding what kinds of proteins you would find these segregation-disrupting mutations. |
b. | How could you use yeast artificial chromosomes (YACs) to find such mutations in S. cerevisiae? |
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b. An example of autosome and heterochromosome
c. An example of homologous chromosome, sister chromatid and centromere.
d. The total number of chromosomes in a metaphase kangaroo cell.
e. A sentence to explain the difference between the terms gene and allele that might apply to this
species.
5) Suppose that in a species of flowering plant, we cross a plant with red flowers with a short stem with a
plant with blue flowers with a long stem. The offspring all have mauve flowers and a long stem. The two
characters, flower color and stem length, are found on different chromosomes.
What can you conclude about the mode of inheritance of each of the characteristics of this plant
species? Incomplete dominance or codominance: C"C", simple A/a dominance
b
If a progeny with long-stemmed mauve flowers from FI is crossed with a plant with
short-stemmed mauve flowers, what proportion of the progeny will have the same genotype as
either of the parents? Compulsory Punnett grid.
ONA and the principles…
a. What is the diploid number of chromosomes for a human?
b. What is the haploid number of chromosomes for a human?
Which cells are considered diploid, gametes or somatic cells?
C.
d. Which cells are considered haploid, gametes or somatic cells?
Explore chromosomal defects among humans in Ensembl at https://www.ensembl.org/index.html?redirect=no(Links to an external site.)
Take a screenshot of one of your findings and describe the type of aberration and its associated phenotype. Identify the locus of gene variant(s) responsible for the disorder.
Screenshot
Name of chromosomal defect
Type of aberration and locus of gene variant(s)
Phenotype
References:
Chapter 12 Solutions
GENETICS(LL)-W/CONNECT >CUSTOM<
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Many proteins other than histones are found...Ch. 12 - What difference exists between the compaction of...Ch. 12 - What is the role of the core histones in...Ch. 12 - a. About how many molecules of histone H2A would...Ch. 12 - The enzyme micrococcal nuclease can cleave...Ch. 12 - a. What letters are used to represent the short...Ch. 12 - About 2000 G bands are visible in a...Ch. 12 - Suppose you performed a fluorescence in situ...Ch. 12 - Which of the following would be suggested by a...
Ch. 12 - For each of the following pairs of chromatin...Ch. 12 - a. Drosophila b. Humans Give examples of...Ch. 12 - One histone modification that is seen consistently...Ch. 12 - Recently, scientists constructed a transgene that...Ch. 12 - Drosophila geneticists have isolated many...Ch. 12 - On the following figures, genes A and B are on the...Ch. 12 - Prob. 17PCh. 12 - The first page of this chapter displays photos of...Ch. 12 - The human genome contains about 3 billion base...Ch. 12 - The mitotic cell divisions in the early embryo of...Ch. 12 - In an experiment published in the journal Cell in...Ch. 12 - a. What DNA sequences are found at the telomeres...Ch. 12 - Prob. 23PCh. 12 - a. In a fluorescent in situ hybridization FISH...Ch. 12 - If you are comparing the two telomeres in each...Ch. 12 - a. What DNA sequences are commonly found at human...Ch. 12 - On the graphs presented in Problem 21, no data is...Ch. 12 - Prob. 29PCh. 12 - Prob. 30PCh. 12 - In the 1920s, Barbara McClintock, later a Nobel...Ch. 12 - Give at least one example of a chromosomal...Ch. 12 - Cornelia de Lange syndrome CdLS is a rare human...Ch. 12 - a. Give at least three examples of types of...Ch. 12 - A number of yeast-derived elements were added to...Ch. 12 - Prob. 36PCh. 12 - The completely synthetic yeast chromosome Syn III...
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- A. Please explain the key differences between each of the following pairs of terms. (i) Haploid vs. monoploid (ii) Pericentric inversion vs. paracentric inversion (Please include a simple diagram, along with your written explanation.) (iii) Homologous chromosomes vs. homeologous chromosomes:arrow_forwardDiseases which are caused by recessive variants in loci located on the X chromosome affect females and males differently. How? Lifestyle choices and environmental exposures can also shape up a disease, how? (Discuss from the aspects of molecular biology) c. In a designed Microarray experiment, in which the probes for the control cell’s transcripts are labelled with green dye and probes for cancer cell’s transcripts are labelled with red dye. What color intensities will you expect in the spots of oncogenes and tumor suppressor genes?arrow_forwardExplain two ways that a chromosomal rearrangement can cause a position effect.arrow_forward
- A. Deletion of the SOX9 gene leads to sex reversal resulting in a person with karyotype 46XY being phenotypically Explain the genetic basis for this. B. Describe what would happen to the phenotype of a male with a mutation in the gene encoding SF1? Explain your answer.arrow_forward● ● Illustrate the chromosome changes in interphase and mitosis using a diploid cell that is 2n=4 (two large and two small chromosomes). Label the circles as G1 and G2 stages of interphase and each phase of mitosis (in order). Draw the chromosome in each circle using the following guidelines. 1) For unreplicated chromosome draw a line (/) and for replicated chromosome draw an X. 2) For simplicity, do not indicate that the chromosomes are decondensed chromatin during interphase. 3) Skip drawing the nuclear membrane or spindle fibers, since we are focusing on the chromosomes. Label genes in the resulting daughter cells as A/a and B/b. (These letters represent genes which are at particular places along the DNA molecule. Each chromosomes can have a thousand genes but we are focusing on these two.) Ask me Qs in class if anythign on this is not clear.arrow_forwardExamine Figure . What type of chromosome (metacentric, submetacentric, acrocentric, or telocentric) is chromosome 1? What about chromosome 4?arrow_forward
- Outline the molecular steps in the process of X-chromosomeinactivation (XCI). Which step plays a key role in choosing whichof the X chromosomes will remain active and which will beinactivated?arrow_forwardDescribe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.arrow_forwardEC4. In a test-cross of trihybrid drosophila the following phenotypes and number of offspring were found. Without doing any calculations, answer the following questions: +++ 669 abc 653 ++c 121 ab+ 139 +b+ 2280 a+c 2215 +bc 3 a++ 2 a) What were the genotypes of the parental strains? (fill in) b). What is the gene order?arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY