Biological Science (7th Edition)
Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 9TYPSS
Summary Introduction

Introduction:

Interphase and metaphase are the two phases of the cell cycle. In interphase, the cell prepares itself for its division, while during metaphase the cell matures its genetic material for replication.

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The following diagram indicates how the cell cycle progresses in typical human cells: INTERPHASE G₁ MITOTIC (M) PHASE Mitosis Cytokinesis DRUG S (DNA synthesis) G2 Suppose that you are investigating potential drugs that might be used to stop the out of control growth of tumor cells. The following table lists several experimental drugs along with some information about their effect on cells. Predict which stage of the cell cycle might be inhibited by each of the drugs (A through E). COMMENTS Shown to block the
You are studying a new fungus, G. lucasus, and are interested the molecules that control the cell cycle of this new organism. You make some mutant cells and find an intriguing mutant that has two mutations - one in the force gene and one in the darkside gene. a. You perform propidium-iodide cell cycle analysis by flow cytometry on wild-type and the double mutant cells and your results are below. During what stage(s) of the cell cycle are the double mutant cells arresting their growth? Please briefly explain your answer. # of cells Wild-Type Cells In 180 kDa 110 kDa 80 kDa b. In studying the gene products of the force and darkside genes, you determine that the force gene produces a polypeptide of 80 kDa, and the darkside gene produces a polypeptide of 42 kDa. You collect lysates from wild-type cells in G₁, S, or G₂/M phases of the cell cycle and perform a Western blot (immunoblot) with either an antibody against force or an antibody against darkside ... only you forget to label your…
Looking at the the time intervals in the figure given, compare the time spent in mitosis with the time spent in gap1 in human liver cells.   A. less time is spent in G1 than in M   B. a little more time is spent in G1 than in M   C. The cell spends 10 hours less in G1 than it does in M   D. The cell spends 10 hours more in G1 than it does in M
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