Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 14PIAT
PROCESS OF SCIENCE Aggressive forms of breast cancer are resistant to Taxol chemotherapy. In these cancers, the gene encoding a protein called stathmin is overexpressed. To investigate the mechanism of action of stathmin, investigators measured tumor volume over time in mice with aggressive cancers under three conditions: no treatment (control), Taxol treatment, and Taxol treatment with stathmin gene expression turned off (Taxol+∆stathmin). Their results are shown below. Use these results to hypothesize how the stathmin protein affects microtubule stability.
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If somatic tumors cause local regions in their vicinity to have an increased pOH, how is this strategic for the survival of the tumor?
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a. It allows the increased hydroxide concentrations to cause a conformational change in nearby hemoglobin to the R state so that ample oxygen is deposited for tumor growth.
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d. It allows the increased hydroxide concentrations to cause a conformational change in nearby hemoglobin to the T state so that ample oxygen is deposited for tumor growth.
e. None of these.
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Chapter 12 Solutions
Biological Science (7th Edition)
Ch. 12 - 1. Which statement about the daughter cells...Ch. 12 - After S phase, what comprises a single chromosome?...Ch. 12 - Progression through the cell cycle is regulated by...Ch. 12 - 4. What major events occur during anaphase of...Ch. 12 - 5. Identify at least two events in the cell cycle...Ch. 12 - 6. What evidence suggests that during anaphase,...Ch. 12 - 7. Evaluate each of the following defects. Which...Ch. 12 - Prob. 8TYUCh. 12 - Prob. 9TYPSSCh. 12 - Prob. 10TYPSS
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