Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 12PIAT
Summary Introduction
To review:
When actively growing cells are treated with Taxol, they often are unable to complete the cell cycle. Explain which checkpoint likely causes these cells to arrest.
Introduction:
The cell-cycle checkpoints are the points or stops in the cell cycle that help in the regulation of cell cycle. The defective checkpoint results in the uncontrolled cell division that could result in tumor formation. The functional check points arrest the cell in a particular stage if there is any defect in that stage of the cell cycle.
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The process of cellular reproduction or divisions is a heavily regulated process for a number of different reasons. In the case of the eukaryotic cell there are a number of different checkpoints that a cell must pass before it can continue on. Please explain what those checkpoints are looking for and where those checkpoints are in the cell cycle. If a cell doesn’t pass any of these checkpoints what happens to those cells?
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True or False?
Chapter 12 Solutions
Biological Science (7th Edition)
Ch. 12 - 1. Which statement about the daughter cells...Ch. 12 - After S phase, what comprises a single chromosome?...Ch. 12 - Progression through the cell cycle is regulated by...Ch. 12 - 4. What major events occur during anaphase of...Ch. 12 - 5. Identify at least two events in the cell cycle...Ch. 12 - 6. What evidence suggests that during anaphase,...Ch. 12 - 7. Evaluate each of the following defects. Which...Ch. 12 - Prob. 8TYUCh. 12 - Prob. 9TYPSSCh. 12 - Prob. 10TYPSS
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- List and briefly describe three major cell cycle checkpoints. For each checkpoint, predict the consequences if the checkpoint fails to work properly.arrow_forwardWhich of the three cell cycle checkpoints represents the most important commitment for the cell to divide? Explain your answer.arrow_forwardThe anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death?arrow_forward
- "Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explainarrow_forward"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.arrow_forwardEven though cytokinesis is included with Mitosis, we generally consider it to be its own phase. Why? by the time cytokinesis occurs, the cell has already split by the time cytokinesis occurs, the cytoplasm has already split by the time cytokinesis occurs, the nucleus has already split by the time cytokinesis occurs, the cell has copied all of its chromosomesarrow_forward
- Which is true for cancer cells: 1) Cell death occurs after a determined number of cell divisions 2) Contact with other cells reduces chance of cell division 3) Cell division occurs in the presence of stop signals.arrow_forwardWhat factors needed to proceed with the cell cycle of G2 checkpoint?arrow_forwardOncologists (cancer doctors) frequently measure the mitotic index of tumor cells when they are removed via surgery or biopsy. What do you think is the value of finding out the mitotic index of these cells?arrow_forward
- Match the phases of the cell cycle to the major events occurring during that phase. G1 phase Growth phase in preparation 1 ♥ S phase DNA synthesis G2 phase Initial growth phase M phase Division of the nucleus Question 4 What is a pH buffer and why are they biologically important? MacBook Air 000 000 F4 F3 F5 F6 F7 F8arrow_forwardWhat is the significance of the cell cycle control system and checkpoints? Explain step by step in your own words. [please make it simple]arrow_forwardThe cell cycle is highly regulated and involves many steps to ensure that a cell is ready to divide. For this reason, cells cycle between interphase and mitosis. Which of the following describes the consequence of a severe disruption of interphase in cells in healthy tissue? Disruption of interphase will have no effect on mitosis because they are two completely independent processes. Disruption of interphase will lead to a faster and more efficient mitotic cycle, which will result in increased cell division and tissue growth. Disruption of interphase will trigger the cell to switch to a mitotic phase and repeatedly divide, which will result in the massive proliferation of the cells and heightened tissue growth. Disruption of interphase will result in the cell being unable to synthesize proteins and organelles required to divide, which will result in the cell not passing key checkpoints and ceasing to divide.arrow_forward
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