Interpretation:
A convergent synthesis, that might produce the same target as shown in Problem 13.38 in a higher yield, is to be constructed.
Concept introduction:
Synthesis may be designed by thinking in the reverse direction, from the product to the starting compound in a method called retrosynthesis. Retrosynthesis starts with the product and a suitable precursor from which it can be synthesized is determined, without considering specific reactions. The precursor must be a simpler molecule, which may or may not have a close structural relation to the target molecule. This process is repeated until an easily available (or easily prepared) precursor is reached. Each of these steps is called a transform. A synthesis is a specific sequence of
For linear synthesis, the overall percent yield is equal to the product of the yields of the individual steps. In a convergent synthesis, portions of a target molecule are synthesized separately and are assembled together at a larger stage. In general, the yield of a multistep synthesis is higher if a target can be produced from a convergent synthesis instead of a linear one.
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ORGANIC CHEMISTRY E-BOOK W/SMARTWORK5
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- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning