Carrying the Cystic Fibrosis Allele Offer Protection from Typhoid Fever Epithelial cells that lack the CFTR protein cannot take up bacteria by endocytosis. Endocytosis is an important part of the respiratory tract’s immune defenses against common Pseudomonas bacteria, which is why Pseudomonas infections of the lungs are a chronic problem in cystic fibrosis patients. Endocytosis is also the way that Salmonella typhi bacteria (shown at right) enter cells of the gastrointestinal tract, where internalization of this bacteria can result in typhoid fever. Typhoid fever is a common worldwide disease. Its symptoms include extreme fever and diarrhea, and the resulting dehydration causes delirium that may last several weeks. If untreated it kills up to 30 percent of those infected. Around 600,000 people, most of whom are children, die annually from typhoid fever. Gerald Pier and his colleagues compared the uptake of S. typhi by different types of epithelial cells: those homozygous for the normal allele, and those heterozygous for the ΔF508 allele associated with CF. (Cells that are homozygous for the mutation do not take up any S. typhi bacteria .) Some of their results are shown in FIGURE 13.16 . FIGURE 13.16 Effect of the ΔF508 mutation on the uptake of three different strains of Salmonella typhi bacteria by epithelial cells. Entry of all three S. typhi strains into the heterozygous epithelial cell was inhibited. Is it possible to tell from this graph which strain was most inhibited?

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
BuyFind

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

Solutions

Chapter 13, Problem 3DAA
Textbook Problem

Carrying the Cystic Fibrosis Allele Offer Protection from Typhoid Fever Epithelial cells that lack the CFTR protein cannot take up bacteria by endocytosis. Endocytosis is an important part of the respiratory tract’s immune defenses against common Pseudomonas bacteria, which is why Pseudomonas infections of the lungs are a chronic problem in cystic fibrosis patients. Endocytosis is also the way that Salmonella typhi bacteria (shown at right) enter cells of the gastrointestinal tract, where internalization of this bacteria can result in typhoid fever.

Typhoid fever is a common worldwide disease. Its symptoms include extreme fever and diarrhea, and the resulting dehydration causes delirium that may last several weeks. If untreated it kills up to 30 percent of those infected. Around 600,000 people, most of whom are children, die annually from typhoid fever.

Gerald Pier and his colleagues compared the uptake of S. typhi by different types of epithelial cells: those homozygous for the normal allele, and those heterozygous for the ΔF508 allele associated with CF. (Cells that are homozygous for the mutation do not take up any S. typhi bacteria.) Some of their results are shown in FIGURE 13.16.

Chapter 13, Problem 3DAA, Carrying the Cystic Fibrosis Allele Offer Protection from Typhoid Fever Epithelial cells that lack , example  1

Chapter 13, Problem 3DAA, Carrying the Cystic Fibrosis Allele Offer Protection from Typhoid Fever Epithelial cells that lack , example  2

FIGURE 13.16 Effect of the ΔF508 mutation on the uptake of three different strains of Salmonella typhi bacteria by epithelial cells.

Entry of all three S. typhi strains into the heterozygous epithelial cell was inhibited. Is it possible to tell from this graph which strain was most inhibited?

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