Explanation Ketone bodies (acetoacetate and β-hydroxybutyrate) except acetone, are produced in the liver cells. However, since the liver lacks the enzyme required for the production of acetyl CoA molecules from the acetoacetate, hence ketone bodies are transported to other organs in the body where such enzymes are present. Ketone bodies like acetoacetate are soluble in water and hence do not require a protein carrier for their transportation. Once the molecule of acetoacetate has reached its destination organ, it requires its activation before it can be used as a fuel...

7th Edition

ISBN: 9781305081079

Author: STOKER, H. Stephen (howard Stephen)

Publisher: Cengage Learning,

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Chapter 14, Problem 14.73EP

Interpretation Introduction

Interpretation:

The name of the reactants and products used in the reaction to activate acetoacetate before being used as a fuel has to be determined.

Concept introduction:

Acetoacetate is a ketone body generated in the mitochondria of the liver cells during ketogenesis. It is the first ketone body to be formed in the body, by the cleavage of a molecule of HMG-CoA The other two ketone bodies, β-hydroxybutyrate and acetone are derived from it. While β-hydroxybutyrate is formed by the reduction of a molecule of acetoacetate by NADH in the liver, acetone is formed by the loss of a carboxyl group from a molecule of acetoacetate in the bloodstream.

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Solution Summary: The author explains the reactants and products used in the reaction to activate acetoacetate before being used as a fuel.

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Chapter 14 Solutions