Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 14, Problem 14TYK
Discuss Concepts During replication, an error uncorrected by proofreading or mismatch repair produces a DNA molecule with a base mismatch at the indicated position:
The mismatch results in a mutation. This DNA molecule is received by one of the two daughter cells produced by mitosis. In the next round of replication and division, the mutation appears in only one of the two daughter cells. Develop a hypothesis to explain this observation.
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Below is a study of a colony of cells, determine that some of these cells have a mutated DNA polymerase I that results in loss of function of this enzyme.
- What will the effect of the mutation in DNA polymerase I be on DNA replication? Include leading and lagging strand
- Will this mutation in DNA polymerase I have an impact on another step in DNA replication? Will DNA be replicatation be impacted? Are any enzymes involved?
Why is DNA replication considered semiconservative?
A. Both strands of each replicating DNA molecules are conserved.
B. One molecule consists of the old strands and the other DNA molecule is entirely new.
C. One strand of each replicating DNA molecule is conserved and the other strand is newly synthesized.
D. Both strands of each replicating DNA molecule are new.
DNA repair processes use the old DNA strand as the template to repair mismatched bases on the newly synthesized strand . A yeast strain (yst150) has a mutation on the gene coding for the enzyme responsible for distinguishing between the old and new strand of DNA . How does the mutation rate of strain yst150 compare with the rate of non-mutant (wild-type ) yeast ? Explain your answer .
Chapter 14 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 14.1 - Prob. 1SBCh. 14.2 - Prob. 1SBCh. 14.2 - Prob. 2SBCh. 14.2 - Prob. 3SBCh. 14.2 - Prob. 4SBCh. 14.3 - What is the importance of complementary base...Ch. 14.3 - Why is a primer needed for DNA replication? How is...Ch. 14.3 - DNA polymerase III and DNA polymerase I are used...Ch. 14.3 - Prob. 4SBCh. 14.4 - Why is a proofreading mechanism important for DNA...
Ch. 14 - Working on the Amazon River, a biologist isolated...Ch. 14 - Prob. 2TYKCh. 14 - Pyrimidines built from a single carbon ring are:...Ch. 14 - Which of the following statements about DNA...Ch. 14 - Which of the following statements about DNA is...Ch. 14 - Prob. 6TYKCh. 14 - Prob. 7TYKCh. 14 - Prob. 8TYKCh. 14 - Prob. 9TYKCh. 14 - Prob. 10TYKCh. 14 - Discuss Concepts Eukaryotic chromosomes can be...Ch. 14 - Prob. 12TYKCh. 14 - Prob. 13TYKCh. 14 - Discuss Concepts During replication, an error...Ch. 14 - Design an Experiment Design an experiment using...Ch. 14 - Prob. 16TYKCh. 14 - Prob. 1ITDCh. 14 - Prob. 2ITD
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- How does DNA replication occur in a precise manner to ensure that identical genetic information is put into the new chromatid? See Figures 8.12 and 8.13. FIGURE 8.12 In DNA replication, the two polynucleotide strands uncoil, and each is a template for synthesizing a new strand. A replicated DNA molecule contains one new strand and one old strand. This mechanism is called semiconservative replication. FIGURE 8.13 A close-up look at the process of DNA replication. (a) As the strands uncoil, bases are added to the newly synthesized strand by complementary base pairing with bases in the template strand. The new bases are linked together by DNA polymerase. (b) DNA synthesis can proceed only in the 5 3 direction; newly synthesized DNA on one template strand is made in short segments and linked together by the enzyme DNA ligase.arrow_forwardIllustrate some steps involved in DNA replication :Suppose the following base sequence was found in a segment of one strand of a DNA molecule: 3’ A-A-T-A-C-C-T-C-C-T-A-A-C-T 5’ What would be the bases in the complementary strand? Label the 3’ and the 5’ ends. Illustrate the DNA molecule below. Label the 3’ and the 5’ ends of both strands. Separate the above DNA molecule up to the seventh base. Add one primer for the leading strand complementary to the first base Adenine of the template strand. Add one primer for the lagging strand complementary to the seventh base Adenine of the template strand. Illustrate the DNA molecule. Label the 3’ and 5’ ends. Elongate the new strands up the seventh base by adding DNA bases complementary to the template strand. Illustrate the resulting DNA molecule. Label the 3’ and the 5’ ends of the template strands and the complementary strands. Elongate the new strands up the seventh base by adding DNA bases complementary to the template strand. Illustrate…arrow_forwardThe diagram shows a model of DNA replication. The diagram points out a number of enzymes and protein factors involved in the process. If this cell were cancerous, a doctor might be using a chemotherapy drug to prevent the replication process from taking place. One such drug, topotecan, inhibits the topoisomerase enzyme from working. Based on the model, if topotecan is used, how will this affect the replication process? A: The hydrogen bonds between the bases will not break B: The double helix of the DNA molecule will not unwind C: It will prevent the addition if complementary nitrogen bases to the leading or lagging DNA strands D: It will prevent the addition of nitrogen bases due to instability of the single-stranded DNA chainsarrow_forward
- Describe three (3) effects on DNA replication if DNA polymerase could build DNA in both directions – in both the 5’ to 3’ direction and the 3’ to 5’ direction.arrow_forwardThe following diagram represents a DNA molecule that is undergoing replication. Draw in the strands of newly synthesized DNA and identify (a) the polarity of the newly synthesized strands, (b) the leading and lagging strands, (c) Okazaki fragments, and (d) RNA primers.arrow_forward. Which of the following statements best describe the mismatch repair pathway?a. It is part of the 3′to 5′proofreading function of DNApolymerase.b. It acts after DNA replication by recognizing mismatched base pairs.c. It is activated by stalled replication forks.d. It is coupled to transcription.arrow_forward
- Once in human cells, which of the following statements might best describe how COVID19 replicates? a) Manipulates DNA Polymerase III to create a leading strand replication of the RNA b) Manipulates DNA Polymerase III to create a lagging strand replication of the RNA c) Manipulates Reverse Transcriptase to transcribe RNA sense strand into DNA antisense strand then back d) Manipulates RNA Polymerase II to transcribe RNA sense strand into RNA antisense strand then back e) Manipulates RNA Polymerase III to transcribe ribosomal RNAs for replicationarrow_forwardwhen a cell to divide, its DNA must be replicated (copied). a.List the most important participating components and their functions in replication b.why is it important that the replication goes right and that relatively few mutations occur during the replication? c.Will the offspring of the individual who received a mutation inherit the mutationarrow_forwardYou conducted an experiment to determine the mechanism of DNA replication in the hypothetical organism Fungus mungus. Your data shows that synthesis of newly replicated DNA from F. mungus is discontinuous on both strands of the replication fork. Does this result support or not support the hypothesis that F. mungus replicates its DNA by the same mechanism as yeast? Briefly explain your answer.arrow_forward
- Which of the following is NOT true of DNA replication? a. Helicase uses ATP as an energy source. b. Primase uses ATP to build primers. c. Single-stranded binding proteins are enzymes that hold the strands open. d. Telomerase adds nucleotides to the original DNA template. e. Ligase uses a condensation reaction to make a single phosphodiester bond at each site of ligation..arrow_forwardList and describe the processes that make up the central dogma of biology which provides the path for the flow of genetic information from DNA to the proteins that are synthesized and carry out the functions needed by the cell.arrow_forwardIn DNA replication, the role of topoisomerase is to Question 11 options: a) "unzip" the double stranded DNA in front of DNA polymerase. b) maintain the single stranded DNA. c) supercoil the DNA after the replication fork has passed. d) relieve supercoil tension in the DNA in front of the replication fork.arrow_forward
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