Essentials of Genetics, Books a la Carte Plus Mastering Genetics with eText -- Access Card Package (9th Edition)
9th Edition
ISBN: 9780134319070
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 14, Problem 20PDQ
Some mutations that lead to diseases such as Huntington disease are caused by the insertion of trinucleotide repeats. Describe how the process of
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explains how the underwinding of a B-DNA helix might facilitate or stabilize the formation of Z-DNA
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Chapter 14 Solutions
Essentials of Genetics, Books a la Carte Plus Mastering Genetics with eText -- Access Card Package (9th Edition)
Ch. 14 - CASE STUDY| Genetic dwarfism Seven months...Ch. 14 -
CASE STUDY | Genetic dwarfism
Seven months...Ch. 14 -
CASE STUDY| Genetic dwarfism
Seven months...Ch. 14 - CASE STUDY | Genetic dwarfism Seven months...Ch. 14 -
HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 14 - Review the Chapter Concepts list on page 257....Ch. 14 - What is a spontaneous mutation, and why are...Ch. 14 -
4. Why would a mutation in a somatic cell of a...Ch. 14 - Why is a random mutation more likely to be...Ch. 14 - Most mutations in a diploid organism are...
Ch. 14 - What is meant by a conditional mutation?Ch. 14 -
8. Describe a tautomeric shift and how it may...Ch. 14 - Contrast and compare the mutagenic effects of...Ch. 14 - Why are frameshift mutations likely to be more...Ch. 14 - Why are X rays more potent mutagens than UV...Ch. 14 -
12. DNA damage brought on by a variety of natural...Ch. 14 - Contrast the various types of DNA repair...Ch. 14 -
14. Mammography is an accurate screening...Ch. 14 - Describe how the Ames test screens for potential...Ch. 14 - What genetic defects result in the disorder...Ch. 14 - In a bacterial culture in which all cells are...Ch. 14 - Human equivalents of bacterial DNA mismatch repair...Ch. 14 - A number of different types of mutations in the...Ch. 14 -
20. Some mutations that lead to diseases such as...Ch. 14 - In maize, a Ds or Ac transposon can cause...Ch. 14 -
22. Presented here are hypothetical findings from...Ch. 14 -
23. Cystic fibrosis (CF) is a severe autosomal...Ch. 14 -
24. Electrophilic oxidants are known to create...Ch. 14 - Skin cancer carries a lifetime risk nearly equal...Ch. 14 -
26. The initial discovery of IS elements in...Ch. 14 -
27. It is estimated that about 0.2 percent of...Ch. 14 -
28. It has been noted that most transposons in...Ch. 14 - Two related forms of muscular dystrophy–Duchenne...
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- DNA contains many hydrogen bonds. Are hydrogen bonds stronger or weaker than covalent bonds? What are the consequences of this difference in strength?arrow_forwardType of DNA spontaneous mutation that can explain why uracil is not found in DNA a.depurination b.methylation c. oxidation d.deaminationarrow_forwardExplain how the chemical structure ofdeoxynucleotides determines the orientation of theDNA strands and how this affects the direction of DNAsynthesis.arrow_forward
- If ligase was defective in a cell, which strand of DNA Replication do you think would be most affected, the leading or lagging strand? Fully explain why you think that by describing the enzyme function and the differences in replication in the leading and lagging strands.arrow_forwardCompare and contrast DNA methylation with DNA acetylation.arrow_forwardName and describe the first four events (and associated enzymes) that happen during DNA replication at the DNA double helix (in correct sequence)arrow_forward
- Single-stranded regions of DNA are attacked by nucleases in the cell, yet portions of DNA are in a singlestranded form during the replication process. Explain.arrow_forwardSuppose a mutation occurs in a cell such that normal Okazaki fragments were created during DNA replication but were not linked together into a continuous strand. Which of the following enzyme is altered by the mutation? Group of answer choices DNA ligase DNA helicase DNA polymerase III RNA primasearrow_forwardDescribe the function of DNA polymerase. Explain why each part of the name DNA polymerase (DNA, polymer, -ase) makes sense.arrow_forward
- If DNA synthesis occurs without error, the resulting double-stranded DNA is an exact copy of the original double-stranded DNA (exact in that the base sequences are identical). Does this mean then that in DNA synthesis, the two single-stranded templates are identical? Explain.arrow_forwardExplain why cuts are made on both sides of the damaged region of the DNA.arrow_forwardConsider how histone proteins bind to DNA and then explain why a salt solution with a high concentration can remove them from DNA (as shown in Figure 12.21b).arrow_forward
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